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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Fig. 4

KLF5 binds to the BACE1 promoter and regulates BACE1 transcription. A Putative KLF5 binding sites on human BACE1 promoter predicted by the JASPAR database. B Schematic of the mutation constructs used to identify the KLF5-binding site on the BACE1 promoter. The mutated sequences are shown. C Promoter activities determined by luciferase assay in HEK293 cells transfected with KLF5 or pcDNA3.1 and human BACE1 promoter luciferase reporter plasmid (−2000 to TSS) or different mutations. D ChIP-qPCR assay of site 4 in SH-SY5Y cells treated with PMA or vehicle for 2 h. Data are mean ± s.e.m of three separate experiments (*P < 0.05, **P < 0.01, and ****P < 0.0001; t-test)

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