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Table 2 Analysis of the relationship between cortical thickness (x 10-1mm) and visual acuity (VA) groupsa

From: Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study

  Global cortical thickness Frontal lobe Temporal lobe Parietal lobe Occipital lobe
ß (95%CI) pb ß (95%CI) pb ß (95%CI) pb ß (95%CI) pb ß (95%CI) pb
All age
 Bad − 0.46 (− 0.84, − 0.09) 0.015 − 0.31 (− 0.70, 0.09) 0.131 − 0.50 (− 1.06, 0.06) 0.079 -0.57 (-1.05, -0.10) 0.018 -0.54 (-0.96, -0.12) 0.011
 Fair 0.01 (− 0.16, 0.19) 0.893 < 0.001 (− 0.19, 0.18) 0.958 − 0.04 (− 0.30, 0.22) 0.780 0.08 (-0.14, 0.30) 0.497 0.02 (-0.17, 0.22) 0.827
 Good Ref. Ref. Ref. Ref. Ref.
pc 0.036 0.296 0.210 0.023 0.025
pd   0.296 0.280 0.050 0.050
Age ≤ 65
 Bad − 0.71 (− 1.24, − 0.17) 0.010 − 0.46 (− 1.03, 0.10) 0.108 − 0.63 (− 1.46, 0.19) 0.130 − 0.83 (− 1.54, − 0.13) 0.021 − 0.99 (− 1.60, − 0.39) 0.001
 Fair − 0.04 (− 0.25, 0.17) 0.696 − 0.05 (− 0.27, 0.18) 0.689 − 0.20 (− 0.52, 0.13) 0.235 0.12 (− 0.16, 0.40) 0.397 − 0.04 (− 0.28, 0.19) 0.722
 Good Ref. Ref. Ref. Ref. Ref.
pc 0.035 0.273 0.209 0.030 0.005
pd   0.273 0.273 0.060 0.002
Age > 65
 Bad − 0.14 (− 0.68, 0.40) 0.615 − 0.09 (− 0.68, 0.50) 0.769 − 0.05 (− 0.82, 0.72) 0.897 − 0.36 (− 1.01, 0.29) 0.278 − 0.08 (− 0.69, 0.53) 0.803
 Fair 0.15 (− 0.15, 0.46) 0.327 0.10 (− 0.24, 0.43) 0.572 0.31 (− 0.12, 0.74) 0.158 0.03 (− 0.33, 0.40) 0.858 0.18 (− 0.16, 0.53) 0.299
 Good Ref. Ref. Ref. Ref. Ref.
pc 0.385 0.726 0.278 0.445 0.449
pd   0.726 0.599 0.599 0.599
  1. CI confidential interval, presented as ([lower value], [upper value])
  2. aGrouped by VA in better-seeing eye: bad = VA ≤ 20/40, fair = 20/40 < VA ≤ 20/25, and good = VA > 20/25 (VA was presented in the Snellen system)
  3. bResult from multivariable linear regression adjusted for age, sex, hypertension, diabetes, dyslipidemia, intracranial volume, and education
  4. cp for trends
  5. dAdjusted p using Benjamini and Hochberg’s method for the multiple tests