Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study

Table 2 Analysis of the relationship between cortical thickness (x 10^-1mm) and visual acuity (VA) groups^a

	Global cortical thickness		Frontal lobe		Temporal lobe		Parietal lobe		Occipital lobe
	ß (95%CI)	p^b	ß (95%CI)	p^b	ß (95%CI)	p^b	ß (95%CI)	p^b	ß (95%CI)	p^b
All age
Bad	− 0.46 (− 0.84, − 0.09)	0.015	− 0.31 (− 0.70, 0.09)	0.131	− 0.50 (− 1.06, 0.06)	0.079	-0.57 (-1.05, -0.10)	0.018	-0.54 (-0.96, -0.12)	0.011
Fair	0.01 (− 0.16, 0.19)	0.893	< 0.001 (− 0.19, 0.18)	0.958	− 0.04 (− 0.30, 0.22)	0.780	0.08 (-0.14, 0.30)	0.497	0.02 (-0.17, 0.22)	0.827
Good	Ref.		Ref.		Ref.		Ref.		Ref.
p^c	0.036		0.296		0.210		0.023		0.025
p^d			0.296		0.280		0.050		0.050
Age ≤ 65
Bad	− 0.71 (− 1.24, − 0.17)	0.010	− 0.46 (− 1.03, 0.10)	0.108	− 0.63 (− 1.46, 0.19)	0.130	− 0.83 (− 1.54, − 0.13)	0.021	− 0.99 (− 1.60, − 0.39)	0.001
Fair	− 0.04 (− 0.25, 0.17)	0.696	− 0.05 (− 0.27, 0.18)	0.689	− 0.20 (− 0.52, 0.13)	0.235	0.12 (− 0.16, 0.40)	0.397	− 0.04 (− 0.28, 0.19)	0.722
Good	Ref.		Ref.		Ref.		Ref.		Ref.
p^c	0.035		0.273		0.209		0.030		0.005
p^d			0.273		0.273		0.060		0.002
Age > 65
Bad	− 0.14 (− 0.68, 0.40)	0.615	− 0.09 (− 0.68, 0.50)	0.769	− 0.05 (− 0.82, 0.72)	0.897	− 0.36 (− 1.01, 0.29)	0.278	− 0.08 (− 0.69, 0.53)	0.803
Fair	0.15 (− 0.15, 0.46)	0.327	0.10 (− 0.24, 0.43)	0.572	0.31 (− 0.12, 0.74)	0.158	0.03 (− 0.33, 0.40)	0.858	0.18 (− 0.16, 0.53)	0.299
Good	Ref.		Ref.		Ref.		Ref.		Ref.
p^c	0.385		0.726		0.278		0.445		0.449
p^d			0.726		0.599		0.599		0.599

CI confidential interval, presented as ([lower value], [upper value])
^aGrouped by VA in better-seeing eye: bad = VA ≤ 20/40, fair = 20/40 < VA ≤ 20/25, and good = VA > 20/25 (VA was presented in the Snellen system)
^bResult from multivariable linear regression adjusted for age, sex, hypertension, diabetes, dyslipidemia, intracranial volume, and education
^cp for trends
^dAdjusted p using Benjamini and Hochberg’s method for the multiple tests

ISSN: 1758-9193