Fig. 9
From: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Increased astrocytosis in tau expressing Abi3-Gngt2−/− mice. Abi3-Gngt2+/+ (WT) and Abi3-Gngt2−/− (KO) mice were injected with control vector (Control) or AAV expressing a double mutant (P301L/S320F) human 0N/4R tau in the cerebral ventricles on neonatal day P0 and analyzed at 3 months or 6 months of age. Representative images of Iba-1 reactive microglia (a–d) and GFAP-reactive astrocyte (e–h) in 3-month-old or 6-month-old mice are shown. Quantitation of the Iba-1 or GFAP staining from forebrain (cortex and hippocampus) is provided in corresponding panels on the right side. N = 6 mice/group. Scale bar, 75 µm. Data represents mean ± sem. One-way ANOVA; ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05