Fig. 8
From: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Abi3-Gngt2 deficiency accelerates tauopathy in a mutant human tau model. Abi3-Gngt2+/+ (WT) and Abi3-Gngt2−/− (KO) mice were injected with control vector (Control) or AAV expressing a double mutant (P301L/S320F) human 0N/4R tau in the cerebral ventricles on neonatal day P0 and analyzed at 3 months (a–f) or 6 months (g–l) of age. Representative brain images indicating total human tau (detected with CP27 antibody, a, g), ptau (detected with CP13 antibody, c, i), and misfolded pretangle tau (detected with MC1 antibody, e, k) from cortex and hippocampus are shown. Quantitative analysis from both cortex and hippocampus of antibody-stained slides (b, d, f, h, j, l) shown on right side of corresponding stained brain images (a, c, e, g, i, k). Scale bar, 75 µm. n = 6 mice/group. Data represents mean ± sem. One-way ANOVA; ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05