Skip to main content
Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

Fig. 1

ABI3 RNA is expressed in microglia and neurons in mice and humans. a, b Abi3 RNA levels (FKPM) plotted across different ages in APP CRND8 mice (a) and MAPT rTg4510 mice (b).

Source data obtained from Mayo RNAseq study (AD Knowledge Portal: n = 9–14 (a) and n = 6 per genotype/age. b. One-way ANOVA, ****p < 0.0001; **p < 0.01; *p < 0.05. cf In situ hybridization was done to detect ABI3 (Fast Red; red color) RNA on human and mouse paraffin-embedded brain sections immunostained with anti Iba-1 antibody (brown color). Arrowheads indicate Iba-1 (microglia) associated in situ signal and arrows indicate in situ signal in non-Iba-1 cells. n = 3 (human AD cases, 6-month-old TG-Abi3-Gngt2/ mice and 6-month-old TG-Abi3-Gngt2+/+ mice) and n = 1 (18-month-old TgCRND8 mice). Representative of two independent experimental replicates. Two separate images are shown from each cohort, indicated as c1-c2, d1-d2, e1-e2, f1-f2. Additional representative images are available in Additional File 4 Fig. S1. NonTG, nontransgenic; TG, transgenic

Back to article page