Table 1 Demographics of participants in the study. N number of participants. Values are shown as mean (standard deviation)
| Â | Non-carriers | Presymptomatic carriers | Symptomatic carriers | ||||
|---|---|---|---|---|---|---|---|
C9orf72 | GRN | MAPT | C9orf72 | GRN | MAPT | ||
N | 61 | 31 | 23 | 23 | 26 | 17 | 12 |
Age at CSF sampling | 44.9 (13.2) | 42.2 (11.1) | 45.3 (13.8) | 40.3 (10.6) | 63.3 (9.2) | 63.1 (7.5) | 61.4 (7.4) |
Sex (% females) | 62.3 | 51.6 | 47.8 | 65.2 | 38.5 | 52.9 | 50 |
CDR plus NACC FTLD sum of boxes | 0.2 (0.5) | 0.3 (0.6) | 0.3 (1) | 0.6 (0.7) | 10.5 (5.6) | 9.4 (5.4) | 8.3 (4.5) |
Plasma NfL (pg/mL) | 8.7 (6.3) | 10.6 (11.8) | 7.5 (3.5) | 7.2 (3.3) | 49.1 (29.2) | 65.1 (54.6) | 19.8 (2.7) |
Total brain volume (as a percentage of total intracranial volume) | 80.8 (3.3) | 79.7 (2.6) | 80.6 (3.1) | 80.9 (2.2) | 72.7 (3.5) | 72.6 (4.2) | 74.5 (3.5) |