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Table 4 Summary table of the main outcome measures for human MEG and simulated MEG

From: A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing

  Human AD AD-like scenarios Contrast scenarios
1A 1B 1C 2A 2B 2C 1A 1B 1C 2A 2B 2C
Parameter   Vd1 EPSP S Vd2 IPSP C2 Vd1 EPSP S Vd2 IPSP C2
Direction   up up up down down down down down down up up up
Neuronal activity n.a. Higher Lower Higher Higher Higher Higher Lower Higher Lower Lower Lower Lower
Oscillatory behavior Slower Slower Slower Slower Slower Faster Slower Faster Faster Faster Faster Slower Faster
Total power Higher (n.s.) Higher Higher Higher Higher Higher Higher Lower Lower Lower Lower Lower Lower
  1. This table shows the direction of change in MEG outcome measures for human MCI and simulated early AD-like or its opposite (contrast) scenarios. Neuronal activity (that is spike density of pyramidal neurons) can only be assessed in model data and show an increase in AD-like scenarios mainly. Of note, the interpretation of the direction (up/down) of parameter modification is intuitive, such that “up” of means hyperexcitability (which is actually derived by lowering the threshold) or stronger coupling. N.a. not available, N.s. not significant, AD Alzheimer’s disease