A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing

Table 4 Summary table of the main outcome measures for human MEG and simulated MEG

This table shows the direction of change in MEG outcome measures for human MCI and simulated early AD-like or its opposite (contrast) scenarios. Neuronal activity (that is spike density of pyramidal neurons) can only be assessed in model data and show an increase in AD-like scenarios mainly. Of note, the interpretation of the direction (up/down) of parameter modification is intuitive, such that “up” of means hyperexcitability (which is actually derived by lowering the threshold) or stronger coupling. N.a. not available, N.s. not significant, AD Alzheimer’s disease

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