Fig. 3

YKL-40 levels in ante-mortem CSF are higher and inversely associated with YKL-40 levels in post-mortem brain. A YKL-40 was quantified by ELISA and corrected for total protein concentration in paired ante-mortem CSF and post-mortem frontal cortex (n = 9). YKL-40 was 8-times higher in CSF compared to post-mortem frontal cortex (B). Scatter plot depicts a correlation between the two matrices; however, this did not reach significance (r = −0.49, p = 0.18). Box represents a median ± interquartile range with bars showing the lowest to highest points, *** p ≤ 0.001. Abbreviations: CSF, cerebrospinal fluid; tot prot. conc, total protein concentration