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Table 3 Differences in protein levels between p-tau subgroups, corrected for age and sex

From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles

Protein (Z-score) Controls (n = 98) Protein level per p-tau group: mean ± standard error of the mean (SE) Contrasts between p-tau subgroups
Differences between p-tau subgroups: mean ± SE p-values of contrasts
Subgroup 1: p-tau ≤ 56 pg/ml (n = 94) Subgroup 2: p-tau 57–96 pg/ml (n = 147) Subgroup 3: p-tau 97–159 pg/ml (n = 89) Subgroup 4: p-tau > 159 pg/ml (n = 11) 1 vs control 2 vs 1 3 vs 1 4 vs 1 3 vs 2 4 vs 2 4 vs 3 1 vs control 2 vs 1 3 vs 1 4 vs 1 3 vs 2 4 vs 2 4 vs 3
BACE1 (n = 439) 0.11 ± 0.1 -0.46 ± 0.09 0.58 ± 0.07 1.44 ± 0.1 2.58 ± 0.27 − 0.57 ± 0.13 1.05 ± 0.12 1.9 ± 0.13 3.04 ± 0.29 0.85 ± 0.12 1.99 ± 0.28 1.14 ± 0.28 1.1E−04 0.0E+00 0.0E+00 0.0E+00 4.1E−11 2.6E−11 4.6E−04
Aβ40 (n = 439) 0.18 ± 0.1 -0.82 ± 0.1 0.32 ± 0.08 1.16 ± 0.1 1.67 ± 0.29 − 0.99 ± 0.14 1.14 ± 0.13 1.98 ± 0.15 2.49 ± 0.31 0.84 ± 0.13 1.35 ± 0.3 0.51 ± 0.31 9.6E−11 0.0E+00 0.0E+00 8.3E−14 3.5E−09 8.2E−05 0.513
NfL (n = 436) 0.13 ± 0.09 0.76 ± 0.09 1.22 ± 0.07 1.83 ± 0.09 2.36 ± 0.25 0.63 ± 0.12 0.47 ± 0.11 1.07 ± 0.12 1.6 ± 0.26 0.61 ± 0.11 1.14 ± 0.26 0.53 ± 0.26 2.8E−06 1.6E−04 7.8E−16 1.6E−08 4.9E−07 8.2E−05 0.262
VAMP2 (n = 396) 0.12 ± 0.1 -0.62 ± 0.1 0.67 ± 0.08 1.64 ± 0.1 2.9 ± 0.29 − 0.74 ± 0.14 1.29 ± 0.13 2.25 ± 0.15 3.52 ± 0.31 0.97 ± 0.13 2.23 ± 0.3 1.27 ± 0.31 2.3E−06 0.0E+00 0.0E+00 0.0E+00 5.7E−12 6.6E−12 3.1E−04
NRGN (n = 439) 0.1 ± 0.09 0.03 ± 0.08 1.41 ± 0.07 2.43 ± 0.09 3.92 ± 0.24 − 0.07 ± 0.12 1.37 ± 0.11 2.4 ± 0.12 3.89 ± 0.26 1.02 ± 0.11 2.51 ± 0.25 1.49 ± 0.26 0.997 0.0E+00 0.0E+00 0.0E+00 0.0E+00 0.0E+00 7.1E−08
  1. Protein levels were natural log-transformed and standardized relative to cognitively normal individuals with normal CSF amyloid, t-tau, and p-tau (controls). Age- and sex-adjusted differences in protein levels between p-tau subgroups were calculated with linear models. p-values of comparisons between p-tau subgroups were adjusted with the Sidak method (considered significant at p-value < 0.05)
  2. CSF, cerebrospinal fluid; BACE1, beta-site amyloid precursor protein cleaving enzyme 1; Aβ40, amyloid-beta 1–40; NfL, neurofilament light; NRGN, neurogranin; VAMP2, vesicle-associated membrane protein 2