From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
Amyloid-negative CN | Preclinical AD | Prodromal AD | AD dementia | |
---|---|---|---|---|
n | 112 | 51 | 102 | 188 |
Age in years, mean ± sd | 58.6 ± 7.8abc | 63.7 ± 7.9ad | 66.9 ± 7.7bdf | 65 ± 7.2cf |
Sex, female (%) | 38 (34%) | 24 (47%) | 35 (34%) | 90 (48%) |
APOE ε4 carriership (%) | 34 (30%)abc | 30 (59%)a | 71 (70%)b | 115 (61%)c |
MMSE, mean ± sd | 28.4 ± 1.4bc | 28 ± 1.4de | 26.4 ± 2bdf | 21 ± 4.4cf |
Amyloid, pg/ml, mean ± sd | 1144 ± 167abc | 651 ± 109ae | 625 ± 100bf | 593 ± 100cf |
T-tau, pg/ml, mean ± sd | 227 ± 85abc | 500 ± 307ae | 554 ± 319bf | 717 ± 398cf |
P-tau, pg/ml, mean ± sd | 40.3 ± 14abc | 72.1 ± 39ae | 75.4 ± 34bf | 86.2 ± 36cf |
T-tau abnormal (%) | 8 (7.1%)abc | 31 (61%)ae | 73 (72%)b | 152 (81%)c |
P-tau abnormal (%) | 9 (8%)abc | 30 (59%)ae | 70 (69%)b | 147 (78%)c |