Fig. 2

P-tau subgroups differ in proteins reflecting amyloid production, synaptic damage, and axonal damage. Controls were cognitively normal individuals with normal CSF amyloid, t-tau, and p-tau. Protein levels were Z-scored relative to controls. The box of the boxplot indicates the 25th percentile, median, and 75th percentile, and whiskers indicate the 1.5× interquartile range. Arrows indicate the protein measurements outside of the y-axis. Differences in the protein levels between p-tau subgroups, and between p-tau subgroups and controls, were calculated with linear models corrected for age and sex. p-values were adjusted for the multiple comparisons between p-tau subgroups with the Sidak method. BACE1, beta-site amyloid precursor protein cleaving enzyme 1; Aβ40, amyloid-beta 1–40; NfL, neurofilament light; VAMP2, vesicle-associated membrane protein 2; NRGN, neurogranin. *p-value < 0.05; **p-value < 0.01; ***p-value < 0.001; n.s., not significant