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Table 2 Autonomic and sensorineural symptoms in the prodromal dementia with Lewy bodies patients’ group (pro-DLB group), compared to the group with only one core feature (1S) and the group without any DLB core feature (NS)

From: Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort

 

NS group (N = 469)

1S group (N = 275)

Pro-DLB group (N = 148)

Comparisons (P-values)

Global

NS vs 1S groups*

NS vs pro-DLB groups*

1S vs pro-DLB groups*

Dry mouth,N(%)

84

(18.5)

80

(29.3)

64

(43.8)

< 0.0001*

0.0024

< 0.0001

0.009

Eye dryness,N(%)

54

(11.9)

62

(22.7)

35

(24.0)

< 0.0001*

0.0005

0.0014

1

Nasal dryness,N(%)

26

(5.8)

31

(11.4)

27

(18.5)

< 0.0001*

0.023

< 0.0001

0.137

Hypersalivation,N(%)

      

< 0.0001*

0.16

< 0.0001

0.0049

 Occasional hypersalivation

11

(2.4)

16

(6.0)

20

(13.8)

    

 Daily hypersalivation

4

(0.9)

1

(0.4)

4

(2.8)

    

Lacrimation,N(%)

      

< 0.0001*

0.0032

< 0.0001

0.23

 Occasional lacrimation

35

(7.6)

41

(15.4)

26

(18.2)

    

 Daily lacrimation

3

(0.7)

3

(1.1)

7

(4.9)

.

   

Rhinorrhea,N(%)

      

< 0.0001*

0.62

< 0.0001

0.0007

 Occasional rhinorrhea

38

(8.3)

28

(10.3)

29

(19.7)

    

 Daily rhinorrhea

9

(2.0)

8

(3.0)

12

(8.2)

    

Photophobia,N(%)

      

< 0.0001*

0.015

< 0.0001

0.008

 Occasional photophobia or with certain types of light

61

(13.2)

58

(21.3)

44

(30.1)

    

 Permanent photophobia or with all types of light

7

(1.5)

5

(1.8)

9

(6.2)

    

Constipation,N(%)

      

< 0.0001*

0.19

< 0.0001

0.0012

 Occasional constipation but not requiring treatment

47

(10.2)

46

(16.9)

26

(17.7)

    

 Frequent constipation requiring the use of laxatives

22

(4.8)

11

(4.0)

25

(17.0)

    

Sexual dysfunction,N(%)

      

< 0.0001*

0.061

0.051

1

 Slightly modified

52

(11.6)

27

(10.5)

20

(14.6)

    

 Severely modified

21

(4.7)

31

(12.1)

25

(18.2)

    

SBP mmHg (Q1–Q3)a

133.5

(122.3; 147.0)

130.5

(118.7; 144.7)

135.3

(119.3; 149.3)

0.144

0.17

1

0.55

DBP mmHg (Q1-Q3)a

77.2

(69.3; 84.0)

76

(69.0; 84.0)

77.3

(69.7; 86.0)

0.50

1

1

0.73

HR bpm (Q1––Q3)a

70.7

(64.7; 79.3)

70.7

(64.3; 79.7)

72

(66.0; 80.0)

0.49

1

0.7

1

Systolic hypotension,N(%)

39

(9.4)

36

(14.5)

20

(16.0)

0.052

0.147

0.123

1

Diastolic hypotensionN(%)

29

(7.0)

26

(10.4)

13

(10.4)

0.24

0.37

0.66

1

Variation in HR at orthostatism in bpm (Q1–Q3)a

7

(3.0; 12.0)

7

(4.0; 12.0)

8

(5.0; 12.0)

0.134

0.39

0.27

1

  1. Abbreviations: Bmp beats per minute, DBP diastolic blood pressure (diastolic hypotension = if DBP decreased by more than 10 mmHg), HR, heart rate, SBP systolic blood pressure (systolic hypotension = if SBP decreased by more than 20 mmHg)
  2. aMedian (Q1 = first quartile − Q3 = third quartile)
  3. *P-values for post hoc pairwise comparisons were adjusted with Bonferoni correction and then rescaled to keep an α = 0.05 statistically significant threshold for readability reason
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Alzheimer's Research & Therapy

ISSN: 1758-9193