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Table 3 Main features of published clinical studies using cortical thickness analysis comparing SCD with HC: sample characteristics, study type and outcomes

From: Grey matter changes on brain MRI in subjective cognitive decline: a systematic review

  Sample Age Sample recruitment Study type Main results
Control SCI Control SCI
Eliassen et al. (2017) [61] - 38 - 59 (8.3) Memory clinic Prospective Focal cortical thinning was found in the bilateral EC in SCD compared with HC.
Fan et al. (2017) 34 43 67.8 (7.4) 66.1 (7.0) Memory clinic Prospective Focal cortical thinning was found in the left parahippocampal, perirhinal and EC and in the right parahippocampal and perirhinal in SCD compared with HC.
Hong et al. (2014) [62] 23 47 66.4 (6.9) 63.2 (7.5) Memory clinic Prospective No significant differences were found between SCD and HC.
Lauriola et al. (2017) [63] 38 32 64.0 (5.1) 64.8 (6.3) Other Prospective Focal cortical thinning was found in the left medial orbitofrontal in SCD compared with HC.
Marcotte et al. (2019) [44] 29 68 70 (6.3) 71 (6.4) Other Prospective No significant differences were found between SCD and HC.
Meiberth et al. (2015) [64] 69 41 66.1 (6.9) 68.9 (7.2) Memory clinic Prospective Focal cortical thinning was found in left EC in SCD compared with HC.
Niemantsverdriet et al. (2018) [65] 93 102 67.3(8.5) 68.6 (9.8) Memory clinic Retrospective No significant differences were found between SCD and HC.
Schultz et al. (2015) [49] 184 77 54.33 (6.10) 54.41 (6.44) Other Prospective Focal cortical thinning was found in the EC, fusiform, posterior cingulate and inferior parietal cortex in SCD compared with HC.
Selnes et al. (2012) [13] 21 16 62 (49-77) 59.2 (45-71) Memory clinic Prospective No significant differences were found between SCD and HC.
  1. Bold text indicates the studies that found statistical differences between SCD and HC participants. Abbreviations: HC Healthy Contols, SCD subjective cognitive decline, EC entorhinal cortex