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Table 2 Main features of published clinical studies using ROI analysis comparing SCD with HC: sample characteristics, study characteristics and outcomes

From: Grey matter changes on brain MRI in subjective cognitive decline: a systematic review

Reference Sample Age Sample recruitment ROIs Study type Type of segmentation Main results
Control SCI Control SCI
Beckett et al. (2015) [31] 189 106 - - Other Hippocampus Retrospective Automated No significant differences were found between SCD and HC.
Caillaud et al. (2020) [32] 30 67 71.9 (5.7) 72.3 (5.1) Other Hippocampus Prospective - No significant differences were found between SCD and HC.
Cantero et al. (2016) [33] 48 47 68.1 (3.2) 69.6 (4.3) Other Hippocampus (parasubiculum presubiculum, subiculum, CA1, CA3, CA4 subfields, DG, HATA, fimbria, ML, fissure and tail) Prospective Automated Volume reductions in the left hippocampus and its CA1, CA4, DG and ML subregions were found in SCD compared with HC.
Cherbuin et al. (2015) [34] 218 165 62.7 (1.3) 62.1 (1.4) Other Bilateral hippocampus Retrospective Manual No significant differences were found between SCD and HC.
Cong et al. (2018) [35] 10 9 69.2 (5.7) 71.3 (6.4) Memory clinic Hippocampus (CA1, CA2, CA3, DG, subiculum, EC, BA35, BA36 and CS) Prospective Automated Volume reductions in the right hippocampus, right DG and right BA35 were found in SCD compared with HC.
Fan et al. (2018) [36, 37] 34 43 67.8 (7.4) 66.1 (7.0) Memory clinic Hippocampus
Amygdala
Prospective Semi-automated No significant differences were found between SCD and HC.
Flier et al. (2004) [38] 28 20 75 (7) 72 (7) Memory clinic Hippocampus
Parahippocampus
Prospective Manual Volume reduction in the left hippocampus was found in SCD compared with HC.
Hafkemeijer (2013) [21, 22] 29 25 71.3 (3.4) 71.4 (9.2) Memory clinic Hippocampus
Amygdala
Thalamus
Putamen
Globus pallidus
Nucleus accumbens
Caudate nucleus
Retrospective Automated Volume reduction in the bilateral hippocampus was found in SCD compared with HC.
Hong et al. (2015) [23] 28 28 70.6 (6.48) 70.9 (6.23) Memory clinic Hippocampus
Cingulate
Corpus callosum
Prospective Manual No significant differences were found between SCD and HC.
Ivanoiu et al. (2015) [39] 31 21 - - Memory clinic Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Jessen et al. (2006) [40] 14 12 66.5 (6.4) 66.1 (7.3) Memory clinic Hippocampus
EC
Prospective Manual Volume reduction in the bilateral EC was found in SCD compared with HC.
Kim et al. (2016) 28 90 70.7 (5.5) 65.8 (8.5) Memory clinic Hippocampus
Amygdala
Prospective Automated Volume reductions in the hippocampus and amygdala were found in SCD compared with HC.
Lindberg et al. (2017) [41] 302 183 73.7 (5.0) 70.5 (5.7) Memory clinic Subiculum Prospective Automated No significant differences were found between SCD and HC.
López-Sanz et al. (2017) [42] 39 41 70.4 (3.7) 71.6 (4.5) Other Hippocampus Prospective Automated No significant differences were found between SCD and HC.
López-Sanz et al. (2016) [43] 63 55 70.7 (4.5) 71 (5) Memory clinic Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Marcotte et al. (2019) [44] 29 68 70 (6.3) 71 (6.4) Other Hippocampus
EC
Prospective Automated No significant differences were found between SCD and HC.
Perrotin et al. (2015) [26] 40 17 69.35 (6.37) 69.12 (8.52) Memory clinic Hippocampus (whole, CA1, subiculum) Prospective Semi-automated Volume reductions in the hippocampus (especially CA1 and subiculum) were found in SCD compared with HC.
Platero et al. (2018) 70 87 70.3 (4.5) 71.7 (5.1) Memory clinic Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Risacher et al. (2020) [45] 31 20 68.8 (4.8) 72.7 (6.4) Other Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Rogne et al. (2016) [46] 58 25 70.6 (6.7) 70 (9.1) Other Hippocampus
Amygdala
Prospective Automated Volume reduction in the hippocampus and increased volume of the lateral ventricles were found in SCD compared with HC.
Ryu et al. (2017) [47] 27 18 70.59 (6.05) 69.89 (6.26) Memory clinic Hippocampus
EC
Prospective Manual Volume reduction in the EC was found in SCD compared with HC.
Saykin et al. (2006) [27] 40 40 71 (5.1) 73.3 (6) Other Hippocampus Prospective Manual No significant differences were found between SCD and HC.
Scheef et al. (2019) [48] 49 24 66 (7.2) 67 (6.1) Memory clinic Cholinergic forebrain
(Ch12 Ch3 Ch4 Ch4p NSP chBFNto)
Prospective Automated Volume reductions in the chBFN (especially in the Ch1/2 and Ch4p nuclei) were found in SCD compared with HC.
Scheef et al. (2012) [28] 56 31 66.4 (7.2) 67.6 (6.2) Memory clinic Hippocampus
Posterior cingulate
Precuneus
Parahippocampus
Prospective Automated Volume reduction in the right hippocampus was found in SCD compared with HC.
Schultz et al. (2015) [49] 184 77 54.33 (6.10) 54.41 (6.44) Other Hippocampus
Amygdala
Prospective Automated Volume reduction in the amygdala was found in SCD compared with HC.
Selnes et al. (2012) [13] 21 16 62 (49–77) 59.2 (45–71) Memory clinic Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Shu et al. (2018) [50] 51 36 62.2 (9.1) 62.2 (9.1) Memory clinic Hippocampus Prospective Automated No significant differences were found between SCD and HC.
Striepens et al. (2010) [51] 48 21 65.8 (7.2) 66.3 (6.1) Memory clinic Hippocampus
EC
Amygdala
Prospective Automated Volume reductions in the bilateral hippocampus, bilateral EC and in the right amygdala were found in SCD compared with HC.
Tepest et al. (2008) [52] 13 14 67.5 (5.5) 66.4 (7.3) Memory clinic Hippocampus (whole, CA1, CA2, CA3, CA4, DC, subiculum) Prospective Manual No significant differences were found between SCD and HC.
van Rooden et al. (2018) [53] 42 25 68(9.2) 68 (9.1) Other Hippocampus Prospective Automated
Manual
No significant differences were found between SCD and HC.
Wang et al. (2006) 50 28 71.9 (5.3) 73 (6.4) Memory clinic Corpus callosum Prospective Semi-automated Volume reduction in the C5 subregion of the corpus callosum was found in SCD compared to HC.
Yue et al. (2018) [54] 67 111 67.7 (6.6) 69.8 (7.6) Other Hippocampus
Amygdala
Temporal horn
Retrospective Automated Volume reductions in the right hippocampus and right amygdala were found in SCD compared with HC.
Zajac et al. (2020) [55] 24 (SCD−) 29 (SCD+) 72.1 (10.4) 71.8 (6.04) Other Hippocampus (hippocampal tail, subiculum, CA1, hippocampal fissure, presubiculum, parasubiculum, molecular layer, granule cell layer/DG, CA3, CA4, fimbria, HATA) Prospective Automated Volume reductions in the left hippocampus and subregions (molecular layer, CA1, CA4, CA3 and tail) were found in SCD compared with HC.
Zhao et al. (2019a) 42 35 64.24 (6.16) 64.53 (7.29) Memory clinic Hippocampus (hippocampal tail, parasubiculum, presubiculum, subiculum, CA1, CA3, CA4, HATA, GC-DG, molecular layer, fimbria, hippocampal fissure) Prospective Automated Volume reductions in the left hippocampus and subregions (hippocampal tail, subiculum, presubiculum, GC-ML-DG and CA4), right presubiculum and right fimbria in SCD compared with HC.
Zhao et al. (2019b) 48 40 64.71 (7.69) 65.08 (7.94) Memory clinic Hippocampus
Amygdala
Lateral ventricle
Third ventricle
Frontal lobe
Occipital lobe
Temporal lobe
Parietal lobe
Cingulate lobe
Insular areas
Prospective Automated Volume reductions in the bilateral hippocampus, amygdala, cingulate, insula, frontal, occipital and temporal lobes in SCD compared with HC.
  1. Bold text indicates the studies that found statistical differences between SCD and HC participants. Abbreviations: BA35 Broadman area 35 (perirhinal cortex), BA36 Broadman area 36 (rhinal sulcus), chBFN cholinergic basal forebrain nuclei, CS collateral sulcus, DG dentate gyrus, EC entorhinal cortex, HATA hippocampal-amygdaloid transition area, HC Healthy Control, ML molecular layer, SCD subjective cognitive decline