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Table 2 Associations of biomarkers with cognitive measures in PSEN1 mutation carriers

From: White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

  MMSE
total score
CERAD Word List Learning Composite
Model summary Adjusted R-squared: 0.90 (p < 0.001) Adjusted R-squared: 0.78
(p < 0.001)
  Std
beta
95% CI p-value Std
beta
95% CI p-value
nWMH volume  − 1.01  − 1.28  − 0.74  < .001***  − 0.54  − 0.94  − 0.14 0.011*
Cortical amyloid (PET) 0.06  − 0.11 0.23 0.484  − 0.05  − 0.31 0.20 0.658
CSF ptau  − 0.09  − 0.25 0.07 0.273  − 0.18  − 0.42 0.07 0.148
Cortical thickness SPL  − 0.08  − 0.35 0.19 0.566 0.21  − 0.19 0.61 0.298
Education 0.09  − 0.05 0.23 0.214 0.24 0.03 0.44 0.027*
  1. Std. beta Standardized beta coefficient, CI Confidence intervals, MMSE Mini-Mental State Exam, nWMH volume Normalized white matter hyperintensity volume, PET Positron emission tomography, CSF Cerebrospinal fluid, ptau Phospho-tau, SPL Superior parietal lobe. *p < 0.05, **p < 0.01, ***p < 0.001