Non-carriersa (N = 21) | Cognitively unimpaired carriersb (n = 20) | Cognitively impaired carriersc (n = 9) | Sig | |
---|---|---|---|---|
Demographics | ||||
Age — mean (SD) | 33.8 (8.7) | 32.6 (8.8) | 47.3 (3.5) | c > a***, c > b*** |
Education — mean (SD) | 11.4 (3.3) | 12.1 (2.6) | 8.7 (4.1) | b > c* |
Female — n (%) | 14 (66.7) | 12 (60.0) | 6 (66.7) | ns |
Cardiovascular risk factors | ||||
High blood pressure — n (%) | 0 (0) | 0 (0) | 0 (0) | ns |
Diabetes — n (%) | 0 (0) | 0 (0) | 0 (0) | ns |
Smoking — n (%) | 1 (4.8) | 2 (10.0) | 2 (22.2) | ns |
BMI — mean (SD) | 23.6 (2.8) | 23.3 (3.8) | 23.8 (2.9) | ns |
Cognitive status | ||||
FAST — median (IQR) | 1 (0.0) | 1 (0.0) | 4 (2) | c > a***, c > b*** |
MMSE — mean (SD) | 29.8 (0.4) | 29.8 (0.7) | 23.3 (3.2) | c < a***, c < b*** |
CERAD Word List Learning Composite — mean (SD) | 36.6 (4.4) | 37.3 (5.4) | 10.8 (5.5) | c < a***, c < b*** |
Neuroimaging markers | ||||
nWMH Vol. *1000 — median (IQR) | 1.07 (0.71) | 0.85 (0.79) | 6.37 (9.15) | c > a***, c > b*** |
Cerebral microbleeds — median (IQR) | 0.0 (0) | 0.0 (0) | 0.0 (0) | ns |
Lacunes — median (IQR) | 0.0 (0) | 0.0 (0) | 0.0 (0) | ns |
Superior parietal lobe cortical thickness — median (IQR) | 2.19 (0.17) | 2.19 (0.17) | 1.80 (0.23) | c < a***, c < b*** |
Cortical amyloid PET (SUVR) — median (IQR) | 0.80 (0.09) | 0.95 (0.27) | 1.13 (0.09) | a < b***, a < c*** |
Cerebrospinal fluid markers | ||||
CSF Aβ42 — median (IQR) | 495.1 (136.1) | 357.8 (190.9) | 233.6 (111.2) | a > b*, a > c** |
CSF ptau — median (IQR) | 18.82 (7.73) | 36.25 (43.63) | 69.40 (66.04) | a < b***, a < c*** |