| | % (95% CI) | | | |
---|
Sample set | Cutoff | Sensitivity | Specificity | PPV | NPV |
---|
Discovery | 0.102 | 96.0 (90.1–98.9) | 83.5 (74.6–90.3) | 85.7 (77.8–91.6) | 95.3 (88.4–98.7) |
Validation | 88.0 (80.0–93.6) | 72.0 (62.1–80.5) | 75.9 (67.0–83.3) | 85.7 (76.4–92.4) |
- The cutoff value was determined by maximizing the Youden Index. The 95% CIs were calculated based on the Clopper-Pearson exact CI
- Abbreviations: Aβ β-amyloid, PET Positron emission tomography, CI Confidence interval, PPV Positive-predictive value, NPV Negative-predictive value