| |
Non-dementia group (n = 179,723)
|
Dementia group (n = 29,865)
|
P
|
|---|
|
Age (years)
|
61.54 ± 7.83
|
70.46 ± 6.59
|
< 0.0001
|
|
BMI (kg/m2)
|
24.26 ± 3.14
|
24.19 ± 3.31
|
< 0.001
|
|
Systolic BP (mmHg)
|
125.01 ± 15.81
|
128.73 ± 16.23
|
< 0.0001
|
|
Diastolic BP (mmHg)
|
76.63 ± 9.98
|
77.77 ± 10.08
|
< 0.0001
|
|
Fasting glucose (mg/dL)
|
99.89 ± 24.24
|
104.63 ± 30.56
|
< 0.0001
|
|
Total cholesterol (mg/dL)
|
206.62 ± 46.60
|
205.47 ± 42.25
|
< 0.0001
|
|
HDL (mg/dL)
|
57.50 ± 35.39
|
56.05 ± 35.84
|
< 0.0001
|
|
LDL (mg/dL)
|
125.28 ± 77.35
|
123.31 ± 81.84
|
< 0.0001
|
|
Smoking status
| | |
0.208
|
|
Never
|
172,482 (95.97)
|
28,606 (95.78)
| |
|
Ex-smoker
|
2121 (1.18)
|
353 (1.18)
| |
|
Current smoker
|
5120 (2.85)
|
906 (3.03)
| |
|
Alcohol consumptiona
| | |
< 0.0001
|
|
None
|
160,398 (89.25)
|
28,075 (94.01)
| |
|
Mild
|
18,428 (10.25)
|
1719 (5.76)
| |
|
Heavy
|
897 (0.50)
|
71 (0.24)
| |
|
Levels of income
| | |
< 0.0001
|
|
Medical aid + 1st quartile (the lowest)
|
37,606 (20.92)
|
5645 (18.9)
| |
|
2nd quartile
|
31,760 (17.67)
|
4842 (16.21)
| |
|
3rd quartile
|
46,044 (25.62)
|
6739 (22.56)
| |
|
4th quartile (the highest)
|
64,313 (35.78)
|
12,639 (42.32)
| |
|
Regular exercise
|
34,103 (18.98)
|
3792 (12.70)
|
< 0.0001
|
|
Hypertension
|
90,215 (50.20)
|
20,248 (67.80)
|
< 0.0001
|
|
Diabetes mellitus
|
26,506 (14.75)
|
7369 (24.67)
|
< 0.0001
|
|
Dyslipidemia
|
70,467 (39.21)
|
12,847 (43.02)
|
< 0.0001
|
|
Age at menarche (years)
|
16.50 ± 1.82
|
16.92 ± 1.79
|
< 0.0001
|
|
Age at menopause (years)
|
49.99 ± 4.07
|
49.27 ± 4.56
|
< 0.0001
|
|
Duration of fertility (years)
|
33.49 ± 4.45
|
32.35 ± 4.95
|
< 0.0001
|
|
Duration of OC use (years)
| | |
< 0.0001
|
|
Never
|
149,286 (83.06)
|
26,008 (87.09)
| |
|
< 1
|
17,771 (9.89)
|
2156 (7.22)
| |
|
≥ 1
|
12,666 (7.05)
|
1701 (5.70)
| |
|
Duration of HRT (years)
| | |
< 0.0001
|
|
Never
|
140,749 (78.31)
|
26,781 (89.67)
| |
|
< 2
|
22,097 (12.30)
|
1735 (5.81)
| |
|
2–5
|
9182 (5.11)
|
663 (2.22)
| |
|
≥ 5
|
7695 (4.28)
|
686 (2.30)
| |
- Data are expressed as the mean ± standard deviation, SD, or n (%)
- Abbreviations: BMI body mass index, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, OC oral contraceptives, HRT hormone replacement therapy
- aAlcohol consumption: mild = up to 30 g (equivalent to 3 drinks) a day; heavy = more than 30 g a day
