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Table 1 Bioenergetic parameters in microglia: initial rates of glucose consumption and lactate production by isolated microglia (nmol/106 cells/min)

From: Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease

 

Dosage impact

Lactate release (nmol/106 cells/min)

Oxidative ATP/glycolytic ATP

Basal

AA

5 μM

∆-lactate (AA-basal )

Control

 

1.10 ± 0.03

2.45 ± 0.05

1.35

1.23

LPS

0.1 μM

1.50 ± 0.06*

2.05 ± 0.07*

0.55

0.36

11 μM

1.35 ± 0.05*

2.15 ± 0.06*

0.8

0.59

808 nm light

10 J/cm2

1.10 ± 0.05

2.43 ± 0.07

1.34

1.24

Aβ + 808 nm light

1 μM + 10 J/cm2

1.2 ± 0.06

2.35 ± 0.08

1.15

0.95

  1. The data are presented as the mean ± SD (n = 8 replicates in each group); *p < 0.05 indicates the data with a statistically significant difference (two-way ANOVA test)