Imipramine vs. other antidepressants | Olanzapine vs. other antipsychotics | |||||
---|---|---|---|---|---|---|
N subjects imipramine; other anti-depressants | Estimate (95% C.I.) | P-val | N subjects olanzapine; other anti-psychotics | Estimate (95% C.I.) | P-val | |
Cognitive exam, ΔMMSE score/year | ||||||
All subjects | 40; 6,233 | 0.4186 (0.0017, 0.8355) | 0.0490 | 94; 798 | 0.4937 (0.0451, 0.9423) | 0.0310 |
APOE4 carriers | 9; 2,748 | 0.6017 (-0.3156, 1.5190) | 0.1985 | 51; 354 | 0.7781 (0.1051, 1.4512) | 0.0235 |
APOE4 non-carriers | 31; 3,485 | 0.1303 (-0.3812, 0.6419) | 0.6175 | 43; 444 | 0.3755 (-0.3011, 1.0520) | 0.2766 |
Clinical diagnosis reversion, hazard ratioa | ||||||
All subjects | 22, 5,476 | 1.4487 (1.2280, 1.7092) | <0.0001 | 74; 679 | 1.7254 (0.7131, 4.1746) | 0.2263 |
APOE4 carriers | 7; 2,635 | 0.8667 (0.4757, 1.5790) | 0.6401 | 41; 308 | 7.0936 (1.0589, 47.5200) | 0.0444 |
APOE4 non-carriers | 15; 2,841 | 1.5313 (1.3976, 1.6778) | <0.0001 | 33; 371 | 1.7422 (0.2738, 11.0870) | 0.9983 |
Clinical diagnosis conversion, hazard ratiob | ||||||
All subjects | 23; 3,987 | 0.9352 (0.7905, 1.1064) | 0.9352 | 24; 191 | 1.3000 (0.8178, 2.0666) | 0.2672 |
APOE4 carriers | 7; 1,482 | 0.5286 (0.2585, 1.0808) | 0.0806 | 11; 57 | 1.9395 (0.9464, 3.9748) | 0.0704 |
APOE4 non-carriers | 16; 2,505 | 1.1177 (0.9240, 1.3521) | 0.2519 | 13; 134 | 0.7770 (0.3500, 1.7246) | 0.5350 |
APOE4 carriers vs. non-carriers | 23; 3,987 | 0.4729 (0.2256, 0.9915) | 0.0474 | 24; 191 | 2.4963 (0.8532, 7.3033) | 0.0949 |