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Table 1 Small molecule inhibitors of apoE4-catalyzed Aβ42 fibrillization

From: Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition

  1. Chemical name, molecular weight, chemical structure, clinical indication (if known), and mechanism of action (if known) of each of the eight hit compounds identified by HTS of the NCC drug library