Table 3 Subgroup analyses of AD risk in the families imposed by APOE and polygenic risk score
From: Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families
Total | Pathogenic variant | No pathogenic variant | ||||
|---|---|---|---|---|---|---|
All | APP/PSEN1 | VUS | Low APOE-risk (<1) | High APOE-risk (>2) | ||
APOE-risk | ||||||
No. of families | 36 | 8 | 6 | 8 | NA | NA |
Mean | 0.96 | 0.29 | 0.10 | 1.44 | NA | NA |
Standard deviation | 0.83 | 0.60 | 0.45 | 0.64 | NA | NA |
vs. Rest, P-value | NA | 0.010* | 0.006* | 0.063 | NA | NA |
Polygenic risk score | ||||||
No. of families | 36 | 8 | 6 | 8 | 11 | 7 |
Mean | 0.05 | 0.03 | −0.22 | 0.18 | −0.001 | 0.16 |
Standard deviation | 0.28 | 0.39 | 0.19 | 0.15 | 0.22 | 0.24 |
vs. Rest, P-value | NA | 0.379 | 0.009* | 0.129 | 0.515 | 0.241 |