Characteristics | ESTHER (N = 5258) | UK Biobank (N = 305,394) |
---|---|---|
n (%)a | n (%)a | |
Age [years] | ||
55–59 | 1020 (19.4) | 90,134 (29.5) |
60–64 | 1504 (28.6) | 120,315 (39.4) |
65–69 | 1577 (30.0) | 92,559 (30.3) |
70–79 | 1157 (22.0) | 2386 (0.8) |
Sex | ||
Female | 2852 (54.2) | 163,705 (53.6) |
Male | 2406 (45.8) | 141,689 (46.4) |
Low-dose ASA use | 962 (18.3) | 57,068 (18.7) |
Number of individuals in household | ||
1 | 854 (16.2) | 63,706 (20.9) |
2 | 3244 (61.7) | 182,426 (59.7) |
>2 | 1160 (22.1) | 59,262 (19.4) |
School education [years] | ||
≤9 | 3915 (74.5) | 91,181 (29.9) |
10–11 | 732 (13.9) | 79,493 (26.0) |
≥12 | 611 (11.6) | 134,720 (44.1) |
BMI [kg/m2] | ||
<25 | 1409 (26.8) | 93,414 (30.6) |
25–<30 | 2543 (48.4) | 134,764 (44.1) |
≥30 | 1306 (24.8) | 77,216 (25.3) |
Smoking | ||
Never | 2757 (52.4) | 157,241 (51.5) |
Former | 1785 (34.0) | 120,990 (39.6) |
Current | 716 (13.6) | 27,163 (8.9) |
Alcohol consumption b | ||
None | 1615 (30.7) | 94,298 (30.9) |
Low or moderate | 3562 (67.7) | 174,310 (57.1) |
High | 81 (1.5) | 36,786 (12.1) |
Physical activity c | ||
Inactive | 991 (18.9) | 44,280 (18.4) |
Low | 2439 (46.4) | 100,178 (41.7) |
Medium or high | 1828 (34.8) | 95,877 (39.9) |
Coronary heart disease | ||
No | 4290 (81.6) | 285,316 (93.4) |
Yes | 968 (18.4) | 20,078 (6.6) |
Hypertension | ||
No | 2235 (42.5) | 202,175 (66.2) |
Yes | 3023 (57.5) | 103,219 (33.8) |
Diabetes | ||
No | 4478 (85.2) | 286,337 (93.8) |
Yes | 780 (14.8) | 19,057 (6.2) |
Depression | ||
No | 4495 (85.5) | 273,742 (89.6) |
Yes | 763 (14.5) | 31,652 (10.4) |
Total cholesterol [mg/dL] | ||
<200 | 1662 (31.6) | 97,264 (31.9) |
200–<240 | 1786 (34.0) | 102,938 (33.7) |
≥240 | 1810 (34.4) | 105,192 (34.4) |
HDL [mg/dL] | ||
<40 | 968 (18.4) | 36,560 (12.0) |
40–<60 | 2614 (49.7) | 156,740 (51.3) |
≥60 | 1676 (31.9) | 112,094 (36.7) |
CRP [mg/L] | ||
<1 | 1339 (25.5) | 107,846 (35.3) |
1–<3 | 2053 (39.1) | 117,782 (38.6) |
≥3 | 1866 (35.5) | 79,766 (26.1) |
APOE genotypes | ||
ε4 non-carrier | 3881 (73.8) | 219,088 (71.7) |
ε2/ε4 or ε3/ε4 | 1295 (24.6) | 79,134 (25.9) |
ε4/ε4 | 82 (1.6) | 7172 (2.4) |