Fig. 3

A Time-activity curves in the whole brain, expressed as standard uptake value (SUV) obtained after administration of [¹⁸F]FSPG to 5xFAD mice at the ages of 2, 5, 8, and 12 months. B–D Box plots representing SUVs in the cortex, hippocampus, and thalamus. * depicts the difference between groups at each time point and # depicts the difference within group with respect to the starting time point (2 months). Probability values are depicted as * (P < 0.05) and ** (P < 0.01). E PET images (representative axial slices) obtained in AD and WT animals after intravenous administration of [¹⁸F]FSPG at different ages. Images have been generated by averaging SUV images of all animals within each group and time point