Fig. 1

Plasma NRG1 levels across groups and correlation to CSF NRG1. A Box plots displaying plasma NRG1 levels across diagnosis groups. Levels were compared using a one-way ANCOVA adjusted on age and sex followed by a post hoc LSD test adjusted for multiple comparisons. B Box plot displaying plasma NRG1 levels in Aβ-positive patients (n = 62) and Aβ-negative patients (n = 55). Levels were compared using a one-way ANCOVA adjusted on age and sex followed by a post hoc LSD test adjusted for multiple comparisons. C ROC curves displaying plasma NRG1 accuracy in differentiating AD patients from neurological controls (AUC = 87.6%, 95% CI: 76.9–98.2%), AD dementia from non-AD dementia patients (AUC = 69.3%, 95% CI: 55.7– 82.3%), AD-MCI from NC (AUC = 88.3%, 95% CI: 77.2–0.99.6%), and AD-MCI from non-AD MCI patients (AUC = 86.4%, 95% CI: 74.7–98.3%). Abbreviations: Aβ, amyloid-beta; AD, Alzheimer’s disease; AUC, area under the curve; MCI mild cognitive impairment; LSD test, least square difference test; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; NRG1, neuregulin 1; ROC, receiver operator characteristics