Table 1 Demographic characteristics of the study participants

Sample size

15

18

47

16

19

Age, y

67.3 ± 9.1

77.4 ± 5.8^a

45,9 ± 15,2

65.5±15.3

67.7±8.6

Gender, F, n (%)

5/15 (33.3%)

10/18 (55.5%)

27/47 (57.4%)

10/16 (62.5%)

10/19 (52.6%)

CSF Aβ42, pg/ml

1002.0 ± 286.6

450.9 ± 67.9^a

N/A

877.2 ± 160.7

499.4 ± 87.0^a

CSF total-tau, pg/ml

262.0 ± 81.0

773.7 ± 406.9^a

N/A

209.2 ± 61.2

577.3 ± 136.1^a

CSF p-tau181 (Innotest), pg/ml

42.5 ± 12.7

91.2 ± 26.2^a

N/A

28.4 ± 8.0

88.9 ± 23.7^a

CSF p-tau181 (Simoa), pg/ml

N/A

N/A

N/A

176.4 ± 57.3

895.8 ± 350.9^a

CSF p-tau231 (Simoa), pg/ml

N/A

N/A

N/A

154.4 ± 49.4

777.9 ± 260.8^a

Plasma p-tau231, pg/ml

6.5 ± 3.4

13.4 ± 5.2^a

N/A

N/A

N/A

Plasma p-tau181, pg/ml

5.8 ± 2.8

10.4 ± 4.1^a

1.1 ± 0.4

N/A

N/A

Serum p-tau231, pg/ml

2.5 ± 2.3

6.4 ± 2.7^a

N/A

1.1 ± 1.1

3.8 ± 4.3^a

Serum p-tau181, pg/ml

4.5 ± 2.0

9.3 ± 3.4^a

0.6 ± 0.3

2.5 ± 2.2

10.1 ± 10.4^a