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Table 3 Relationships between nEV Aβ42 and AV45 SUVR

From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

  β Standard error Standard β t p
The plasma nEV Aβ42 term alone explained 41.1% variation in average AV45 uptake
Intercept 1.109 0.011   104.429 < 0.001
nEV Aβ42 0.028 0.003 0.641 10.921 < 0.001
The plasma nEV Aβ42 plus clinical features explained 46.4% variation in average AV45 uptake
Intercept 0.939 0.071   13.225 < 0.001
nEV Aβ42 0.025 0.003 0.573 9.695 < 0.001
Age 0.003 0.001 0.154 2.691 0.008
Female − 0.011 0.015 − 0.043 − 0.763 0.447
APOE ε4 status 0.041 0.015 0.165 2.819 0.005
The plasma nEV Aβ42 plus clinical features and the interaction term explained 46.6% variation in average AV45 uptake
Intercept 0.915 0.077   11.986 < 0.001
nEV Aβ42 0.029 0.005 0.651 5.986 < 0.001
Age 0.003 0.001 0.166 2.815 0.005
Female − 0.01 0.015 − 0.039 − 0.691 0.491
APOE ε4 status 0.055 0.022 0.221 2.517 0.013
nEV Aβ42 * APOE ε4 status − 0.005 0.006 − 0.121 − 0.858 0.392
  1. The analysis was performed in total individuals including Aβ− NCs, Aβ+ NCs, and patients with aMCI and ADD. In the first model, nEV Aβ42 was used as a predictor of AV45 SUVR; in the second model, nEV Aβ42 plus age, sex, and APOE ε4 status were used as predictors of AV45 SUVR; in the third model, the interaction term between nEV Aβ42 and APOE ε4 status was additionally included
  2. Abbreviations: β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AV45 [18F]florbetapir