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Table 2 ROC curves

From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Categorical variables

AUC (Aβ− NCs vs. aMCI)

AUC (NCs vs. aMCI)

AUC (NCs vs. ADD)

nEV Aβ42

85.67% (78.36–92.98%)

79.12% (71.33–86.92%)

91.48% (86.76–96.2%)

nEV Aβ42 + APOE ε4 status

87.39% (80.39–94.39%)

79.97% (72.08–87.85%)

90.4% (84.74–96.06%)

Age + sex + APOE ε4 status (model 1)

70.72% (59.66–81.79%)

65.74% (55.12–76.35%)

76.6% (64.64–88.55%)

Model 1 + MMSE + MoCA-B + N5 + N7

96.77% (94.08–99.47%)

97.25% (95.17–99.33%)

99.78% (99.45–100%)

  1. ROC curves were used to distinguish Aβ− NCs from aMCI individuals, NCs from aMCI individuals, and NCs from ADD individuals. AUC and its corresponding 95% CIs are listed
  2. Abbreviations: Aβ β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, MMSE Mini-Mental State Examination, MoCA-B Montreal Cognitive Assessment-Basic Version, N5 auditory verbal learning test-delayed memory, N7 auditory verbal learning test-recognition, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AUC area under the curve, ROC receiver operating characteristic, CI confidence interval
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Alzheimer's Research & Therapy

ISSN: 1758-9193