Fig. 2From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosisPlasma Aβ concentrations in different diagnostic groups. In the current nEV study, 180 subjects (81 Aβ− NCs, 45 Aβ+ NCs, 34 aMCI, and 20 ADD individuals) had previously undergone plasma Aβ40 (A) and Aβ42 (B) quantification. C The ratio of Aβ42 to Aβ40 among the different diagnostic groups. Statistical analysis was conducted using the Kruskal–Wallis H test, followed by multiple post hoc comparisons (adjusted p value). Comparisons among groups: *p < 0.05; ns, > 0.05. Furthermore, a correlation analysis was performed between the Aβ42 to Aβ40 ratio and AV45 SUVR among the different groups (D). The correlation coefficients and p values are listed. Aβ, β-amyloid; NCs, cognitively normal controls; aMCI, amnestic mild cognitive impairment; ADD, Alzheimer’s disease dementia; nEV, neuronal-derived extracellular vesicle; AV45, [18F]florbetapir; SUVR, standardized uptake value ratioBack to article page