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Table 3 Dementia risk/protective factors and Alzheimer’s disease cognitive and neuroimaging markers associated with the times spent in each state

From: Dynamic functional connectivity patterns associated with dementia risk

   Mean dwell time in the state Total time in the state
Standardized (95% CI) P Adj R2   Standardized (95% CI) P Adj R2
State 1 Model 1     Model 1    
  Step 1     Step 1    
  Mid-life CAQ −1.93
−2.01
(−3.64 to −0.22)
0.03 0.02 Early-life CAQ −0.24
(−0.03 to −0.004)
0.007 0.03
      Step 2    
      Early-life CAQ −0.22
(−0.02 to −0.003)
0.01
      LDL cholesterol 0.20
(0.003 to 0.11)
0.04 0.06
  Model 2     Model 2    
  
State 2 Model 1     Model 1    
  Step 1     Step 1    
  SBP 0.21
(0.02 to 0.26)
0.02 0.02 SBP 0.23
(0.0005 to 0.004)
0.01 0.03
  Step 2     Step 2    
  SBP 0.26
(0.04 to 0.29)
0.007 SBP 0.21
(0.0003 to 0.004)
0.02  
  BMI −0.19
(−1.14 to −0.03)
0.04 0.05 GDS 0.19
(0.002 to 0.04)
0.03 0.06
      Step 3    
      SBP 0.26
(0.0008 to 0.005)
0.006
      GDS 0.19
(0.002 to 0.04)
0.03
      BMI −0.19
(−0.02 to −0.0007)
0.02 0.08
  Model 2     Model 2    
   
State 3 Model 1     Model 1    
Step 1     Step 1    
BMI 0.23
(0.14 to 1.06)
0.01 0.04 Early-life CAQ 0.24
(0.003 to 0.02)
0.007 0.4
Step 2     Step 2    
BMI 0.23
(0.16 to 1.06)
0.008 Early-life CAQ 0.24
(0.003 to 0.02)
0.006
Early-life CAQ 0.24
(0.18 to 1.06)
0.006 0.09 BMI 0.20
(0.001 to 0.02)
0.02 0.08
Model 2     Model 2    
  Step 1     Step 1    
  PACC5 1.80
(0.64 to 7.77)
0.02 0.03 PACC5 0.22
(0.006 to 0.12)
0.03 0.05
State 4 Model 1     Model 1    
  Step 1     Step 1    
Mid-life LEQ 0.23
(0.06 to 0.48)
0.01 0.04 Mid-life LEQ 0.25
(0.002 to 0.01)
0.006 0.04
Step 2     Step 2    
Mid-life LEQ 0.19
(0.01 to 0.43)
0.04 Mid-life LEQ 0.24
(0.002 to 0.01)
0.008
SBP −0.21
(−0.20 to −0.02)
0.02 0.07 LDL cholesterol −0.21
(−0.08 to −0.005)
0.03 0.07
–– Model 2 - Model 2 -
  1. Results of the forward stepwise regression models performed using the temporal DFNC parameters as the dependent variable (mean dwell time and total time) for each state (from state 1 to state 4). Model 1 corresponds to the model with dementia risk and protective factors as predictive variables adjusted for age and sex. Model 2 corresponds to the model with Alzheimer’s disease cognitive and neuroimaging markers as predictive variables, adjusted for age, sex, and education. Adj adjusted, CAQ Cognitive Activity Questionnaire, LEQ Lifetime of Experiences Questionnaire, PACC5 Preclinical Alzheimer’s Cognitive Composite score-5, LDL low-density lipoprotein, SBP systolic blood pressure