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Table 3 Correlations of CSF lactate with variables of interest for subsamples

From: Cerebrospinal fluid lactate levels along the Alzheimer’s disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers

 

ADD

MCI-AD

FTLD

HC

all

Age [years]

0.133

0.028

0.150

0.179

0.156**

p = 0.148

p = 0.782

p = 0.396

p = 0.179

p = 0.006

MMSE [points]

− 0.054

0.019

− 0.208

0.035

− 0.007

p = 0.562

p = 0.851

p = 0.238

p = 0.794

p = 0.905

Albumin CSF/serum

0.216*

0.081

0.501**

0.302*

0.207***

p = 0.018

p = 0.422

p = 0.003

p = 0.021

p < 0.001

CSF Aβ42 [pg/nl]

− 0.143

− 0.023

0.066

− 0.008

− 0.104

p = 0.121

p = 0.819

p = 0.712

p = 0.951

p = 0.067

CSF t-Tau [pg/nl]

− 0.030

− 0.064

0.032

0.275*

0.070

p = 0.749

p = 0.525

p = 0.859

p = 0.036

p = 0.220

  1. *Significant at p<0.05
  2. **Significant after Bonferroni correction on group level (p<0.05/5= <0.01)
  3. ***Significant after Bonferroni correction across groups (p<0.05/25= <0.002)