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Table 2 Descriptive values of demographics, MMSE scores, and CSF analyses

From: Cerebrospinal fluid lactate levels along the Alzheimer’s disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers

  

ADD

MCI-AD

FTLD

HC

n (%f)

 

119 (59.7)

101 (47.5)

34 (58.8)

58 (34.5)

Age [years]

M (SD)

66.4 (9.5)

68.4 (10.0)

66.2 (8.6)

59.1 (13.7)

MD (IQR)

67 (60–73)

72 (82–76)

64.0 (59.3–74.0)

60.5 (51.0–70.8)

Range

40–89

41–84

46–83

30–85

MMSE [points]

M (SD)

19.5 (4.8)

26.8 (1.3)

20.5 (6.6)

29.5 (0.7)

MD (IQR)

21 (18–23)

27 (60–28)

22.5 (16.3–26.0)

30.0 (29.0–30.0)

Range

1–24

25–30

2–30

28–30

CSF lactate [mmol/l]

M (SD)

1.75 (0.25)

1.83 (0.24)

1.79 (0.23)

1.73 (0.31)

MD (IQR)

1.72 (1.60–1.90)

1.80 (1.69–1.95)

1.80 (1.63–1.93)

1.69 (1.50–1.90)

Range

1.20–1.70

1.30–2.60

1.30–2–27

1.10–2.70

Albumin CSF/serum

M (SD)

6.82 (2.63)

6.61 (2.56)

6.23 (2.19)

6.91 (2.92)

MD (IQR)

6.38 (4.87–8.22)

5.88 (4.80–7.56)

5.81 (4.78–6.80)

5.94 (4.83–8.32)

Range

2.55–14.40

2.98–13.20

3.32–13.10

2.68–14.30

CSF Aβ42 [pg/nl]

M (SD)

464 (116)

452 (110)

662 (438)

1029 (252)

MD (IQR)

471 (393–552)

469 (368–551)

662 (470–975)

1029 (816–1219)

Range

226–649

182–638)

334–2352

670–1714

CSF t-Tau [pg/nl]

M (SD)

797 (638)

554 (360)

685 (706)

262 (101)

MD (IQR)

630 (397–991)

461 (342–680)

451 (331–659)

246 (183–314)

Range

122–4635

37–1708

70–3600

108–551

  1. n number, f female, m male, M mean, SD standard deviation, MD median, IQR interquartile range, ADD Alzheimer’s disease dementia, MCI-AD mild cognitive impairment due to Alzheimer’s disease, FTLD frontotemporal lobar degeneration, HC healthy controls