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Table 2 Correlation between CSF levels of PSD-95, SNAP-25, or neurogranin and CSF AD biomarkers

From: Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease

 

PSD-95

SNAP-25

Neurogranin

r

r2

p

r

r2

p

r

r2

p

NfL

0.08

0.01

n.s.

−0.01

0

n.s.

−0.08

0.01

n.s.

GFAP

0.06

0

n.s.

0.13

0.02

n.s.

0.08

0.01

n.s.

Aß42/40 ratio

−0.37

0.13

0.026

−0.39

0.16

0.015

−0.53

0.29

0.0007

pTau181

0.57

0.32

0.0002

0.81

0.66

<0.0001

0.69

0.47

<0.0001

tTau

0.6

0.36

0.0001

0.92

0.84

<0.0001

0.86

0.74

<0.0001

  1. Abbreviations: NfL neurofilament light, GFAP glial fibrillary acidic protein, Aß42/40 ratio amyloid ß42/40 ratio, pTau181 Phospho-Tau 181, tTau total tau
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Alzheimer's Research & Therapy

ISSN: 1758-9193