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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis

Fig. 4

Metabolic connectivity of the DMN and SN. A ICA estimates of the difference at the voxel level in the DMN and SN network between MAPT carriers and non-carriers (uncorrected p < 0.005) and between bvFTD patients and controls (FWE p < 0.05). The significant difference between subjects with MAPT carriers > non-carriers is shown in red. Blue highlights the differences for subjects with MAPT carriers < non-carriers and bvFTD patients < controls. B Differences in connectivity within the DMN and SN in MAPT carriers compared with non-carriers and bvFTD patients compared with controls using non-parametric permutation tests with 5000 permutations (p < 0.05), which are represented on a 3D brain template using the BrainNet toolbox. Increased metabolic connections are represented by red lines, decreased metabolic connections by blue lines

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Alzheimer's Research & Therapy

ISSN: 1758-9193