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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis

Fig. 2

Characteristics of the reorganized hubs. A Graph analysis of properties of the nodes that were consistently reorganized in asymptomatic MAPT carriers and FTD patients, including lost and reconfigured hubs. B In asymptomatic MAPT carriers, lost hubs had weakened connections with the vlPFC, vPFC, vFC, dlPFC, IPL, IPS, temporal lobe, and occipital lobe, whereas reconfigured hubs had enhanced connections with components of the frontal cortex, including the vmPFC, dlPFC, dFC, vlPFC, aPFC, vFC, orbitofrontal cortex, rectus gyrus, and ACC. Enhanced metabolic connections are represented by yellow lines, and weakened metabolic connections are represented by blue lines. vlPFC, ventrolateral prefrontal cortex; vPFC, ventral prefrontal cortex; vFC, ventral frontal cortex; dlPFC, dorsolateral prefrontal cortex; IPL, inferior parietal lobule; IPS, intraparietal sulcus; vmPFC, ventromedial prefrontal cortex; dFC, dorsal prefrontal cortex; aPFC, anterior prefrontal cortex; ACC, anterior cingulate cortex

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Alzheimer's Research & Therapy

ISSN: 1758-9193