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Table 2 Multivariate analysis including all OCT outcomes statistically significant in the univariate analysis

From: The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

  

Ratio AB 1–42/40

pTau

tTau

Hippocampal volume

Beta (95%CI)

p-value

Beta (95%CI)

p-value

Beta (95%CI)

p-value

Beta (95%CI)

p-value

BMO-MRW

TS

3.22E−5 (− 5.12E−5 to 11.6E−5)

0.444

− 0.07 (− 0.16 to 0.02)

0.111

− 042 (− 0.92 to 0.07)

0.092

0.26 (− 1.03 to 1.56)

0.688

T

2.82E−5 (− 8.35E−5 to 14.0E−5)

0.503

− 0.02 (− 0.14 to 0.11)

0.812

− 0.14 (− 0.81 to 0.54)

0.687

0.40 (− 1.36 to 2.16)

0.651

TI

3.16E−5 (− 5.08E−5 to 11.4E−5)

0.448

0.01 (− 0.08 to 0.10)

0.800

− 0.01 (− 0.51 to 0.49)

0.968

0.49 (− 0.80 to 1.79)

0.448

NI

2.4E−5 (− 4.84E−5 to 9.71E−5)

0.006

0.02 (− 0.06 to 0.10)

0.672

0.07 (− 0.37 to 0.51)

0.756

0.80 (− 0.32 to 1.92)

0.158

N

4.04E−5 (− 3.06E−5 to 11.1E−5)

0.261

− 0.03 (− 0.11 to 0.05)

0.425

− 0.21 (− 0.63 to 0.22)

0.336

0.99 (− 0.09 to 2.07)

0.071

NS

6.64E−5 (− 3.06 to 13.5E−5)

0.056

− 0.07 (− 0.15 to 0.01)

0.073

− 0.56 (− 0.78 to 0.07)

0.099

0.76 (− 0.37 to 1.89)

0.183

RNFL

TS

− 9.23E−5 (− 32.5E−5 to 14.1E−5)

0.434

0.08 (− 0.18 to 0.34)

0.561

0.49 (− 0.90 to 1.88)

0.485

1.18 (− 2.63 to 4.98)

0.539

T

− 13.8E−5 (− 0.001 to 27.1E−5)

0.505

0.32 (− 0.12 to 0.78)

0.150

2.22 (− 0.18 to 4.61)

0.069

− 0.19 (− 7.00 to 6.60)

0.954

TI

7.68E−5 (− 10.7E−5 to 26.1E−5)

0.408

− 0.17 (− 0.37 to 0.04)

0.108

− 0.97 (− 2.05 to 0.11)

0.076

3.77 (0.90 to 6.63)

0.011*

NI

5.71E−5 (− 11.0E−5 to 22.5E−5)

0.500

− 0.15 (− 0.33 to 0.04)

0.120

− 1.02 (− 2.00 to −0.41)

0.041

3.38 (0.75 to 6.01)

0.013*

N

5.08E−5 (− 23.7E−5 to 33.8E−5)

0.726

− 0.04 (− 0.36 to 0.28)

0.813

− 0.76 (− 2.47 to 0.94)

0.337

6.81 (2.45 to 11.17)

0.003*

NS

0.00 (− 7.63E−5 to 31.5E−5)

0.228

− 0.10 (− 0.32 to 0.12)

0.364

− 0.71 (− 1.87 to 0.46)

0.232

4.25 (0.96 to 7.54)

0.012*

CGL

TS 1

− 1.94E−5 (− 0.001 to 0.001)

0.959

− 0.53 (− 1.36 to 0.29)

0.200

− 2.26 (− 6.70 to 2.18)

0.314

17.13 (5.69 to 25.57)

0.004

TS 2

− 8.72E−5 (− 0.001 to 0.001)

0.823

− 0.37 (− 1.23 to 0.48)

0.390

− 1.97 (− 6.57 to 2.64)

0.398

15.58 (3.54 to 27.62)

0.012*

NS 3

0.00 (− 0.001 to 0.001)

0.722

− 0.12 (− 1.09 to 0.86)

0.811

− 0.88 (− 6.13 to 4.36)

0.738

17.85 (3.89 to 31.81)

0.013*

NS 4

0.00 (− 0.001 to 0.001)

0.744

− 0.12 (− 1.13 to 0.89)

0.812

− 0.73 (− 6.14 to 4.67)

0.788

17.33 (2.51 to 32.16)

0.023*

TS 5

4.14E−5 (− 0.001 to 0.001)

0.902

− 0.41 (− 1.15 to 0.32)

0.268

− 2.61 (− 6.56 to 1.35)

0.193

14.66 (4.58 to 24.74)

0.005*

TS 6

0.00 (0.000 to 0.001)

0.123

− 0.78 (− 1.49 to −0.07)

0.032

− 3.57 (− 7.42 to 0.28)

0.069

4.23 (− 6.25 to 14.70)

0.424

NS 7

0.00 (0.000 to 0.001)

0.193

− 0.65 (− 1.36 to 0.05)

0.070

− 3.25 (− 7.07 to 0.57)

0.094

6.08 (− 4.28 to 16.44)

0.246

NS 8

− 1.56E−5 (− 0.001 to 0.001)

0.971

− 0.44 (− 1.40 to 0.52)

0.361

− 3.08 (− 8.21 to 2.05)

0.235

18.93 (5.68 to 32.19)

0.006*

TI 9

0.00 (0.000 to 0.001)

0.516

− 0.88 (− 1.69 to −0.08)

0.032

− 4.76 (− 9.07 to −0.44)

0.031

13.26 (1.75 to 24.77)

0.025*

TI 10

0.00 (− 0.001 to 0.001)

0.726

− 0.46 (− 1.21 to 0.28)

0.219

− 1.49 (− 5.51 to 2.54)

0.465

2.79 (− 8.02 to 13.62)

0.608

NI 11

0.00 (0.000 to 0.001)

0.705

− 0.37 (− 1.04 to 0.31)

0.285

− 1.61 (− 5.25 to 2.04)

0.384

4.06 (− 5.70 to 13.82)

0.410

NI 12

0.00 (− 0.001 to 0.001)

0.480

− 0.69 (− 1.63 to 0.26)

0.150

− 3.87 (− 8.94 to 1.19)

0.132

13.53 (0.01 to 27.05)

0.050

TI 13

0.00 (− 0.001 to 0.001)

0.494

− 1.04 (− 2.05 to −0.02)

0.045

− 5.43 (− 10.89 to 0.03)

0.051

20.42 (5.70 to 35.14)

0.007*

TI 14

0.00 (− 0.001 to 0.001)

0.567

− 0.81 (− 1.70 to 0.08)

0.073

− 4.65 (− 9.42 to 0.11)

0.055

16.39 (3.68 to 29.10)

0.012*

TI 15

3.81E−5 (− 0.001 to 0.001)

0.926

− 0.75 (− 1.65 to 0.14)

0.097

− 4.38 (− 9.17 to 0.41)

0.073

14.24 (1.37 to 27.12)

0.031*

TI 16

0.00 (− 0.001 to 0.001)

0.458

− 0.70 (− 1.65 to 0.25)

0.146

− 3.43 (− 8.54 to 1.69)

0.187

16.04 (2.23 to 29.85)

0.023*

  1. Significative values (p < 0.005) are in bold
  2. Significative values after the false discovery rate are distinguished with an asterisk
  3. Abbreviations: BMO-MRW, Bruch’s membrane opening-minimum rim width; GCL, ganglion cell layer; I, inferior; N, nasal; RNFL, retinal nerve fiber layer; S, superior; T, temporal