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Table 1 Demographics and characteristics of the Aβ− cognitively unimpaired cohort split by the 90%ile Me SUVR

From: Mesial temporal tau in amyloid-β-negative cognitively normal older persons

 

90%ile Me SUVR

Lower 90%

(n = 179)

Top 10%

(n = 20)

Age (years)

74.3±5.0

78.3±5.7**

Sex, F n (%)

99 (55.3%)

14 (70.0%)

APOE ε4+, n (%)a

40 (22.3%)

6 (30.0%)

Education (years)

14.3±3.1

13.5±3.2

HV (cm3)b

2.97±0.3

2.82±0.2**

Centiloid

2.02±7.0

3.36±11.1

SMC, n (%)

102 (57.0%)

11 (55.0%)

  1. Abbreviations: Me mesial temporal composite, SUVR standardized uptake value ratio, APOE apolipoprotein E, HV hippocampal volume, SMC subjective memory complaint
  2. Mean (SD), unless otherwise specified. *p ≤ 0.05, **p ≤ 0.01 compared to the lower 90% group
  3. aAPOE data was not available for 3 participants in the lower 90% group
  4. bHV was only available for 17/20 participants in the top 10% group and 153/179 participants in the lower 90% group. Results remain significant after correction for age (p = 0.04); effect size, Cohen’s d = 0.34
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Alzheimer's Research & Therapy

ISSN: 1758-9193