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Table 4 Neuropsychiatry inventory sleep disturbance scores by APOE ε4 status

From: APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia

  Non-ε4 carrier
n=96
ε4 Heterozygosity
n=95
ε4 Homozygosity
n=11
p value*
0 vs 1 ε4 Alleles 1 vs 2 ε4 Alleles 0 vs 2 ε4 Alleles
NPI K Global Score (SD) 1.36 (3.3) 2.03 (4.0) 4.55 (5.4) 0.236 0.107 0.024
NPI K Severity Score (SD) 0.42 (0.9) 0.57 (1.0) 1.27 (1.5) 0.135 0.034 0.013
NPI K Frequency Score (SD) 0.67 (1.4) 0.92 (1.6) 1.64 (1.9) 0.103 0.029 0.008
NPI K Caregiver Distress Score (SD) 0.39 (1.2) 0.53 (1.3) 1.00 (1.7) 0.003 0.007 <0.001
  1. *p values calculated by Wilcoxon rank-sum test