Skip to main content

Table 2 Sex differences in the severity of neuropsychiatric symptoms in Alzheimer’s disease dementia

From: Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis

NPS

k

Hedges’ g [95% CI]a

z statistic

P

Q statistic

P Q statistic

I2 statistic

Total score NPS measure (outlier excluded)

13

0.04 [− 0.04, 0.12]

1.03

0.31

7.54

0.82

0.00

Depressive symptoms (outlier excluded)

16

0.24 [0.14, 0.34]

4.59

< 0.001

30.15

0.02

44.29

Delusions (outlier excluded)

10

0.19 [0.04, 0.34]

2.53

0.01

19.99

0.02

58.78

Aberrant motor behavior (outlier excluded)

9

0.17 [0.08, 0.26]

3.56

< 0.001

3.25

0.92

0.00

Anxiety (outlier excluded)

10

0.11 [0.00, 0.22]

1.98

0.05

13.27

0.01

25.15

Sleep disturbances

6

0.11 [− 0.02, 0.24]

1.62

0.11

5.66

0.34

21.77

Disinhibition (outlier excluded)

10

0.08 [− 0.05, 0.21]

1.16

0.25

17.01

0.05

46.48

Eating behavior

6

0.07 [− 0.04, 0.18]

1.28

0.20

3.23

0.67

0.00

Hallucinations (outlier excluded)

10

0.07 [− 0.13, 0.26]

0.65

0.51

36.63

< 0.001

77.20

Agitation (outlier excluded)

11

0.01 [− 0.07, 0.10]

0.26

0.79

12.53

0.25

3.12

Irritability

11

0.00 [− 0.08, 0.07]

− 0.10

0.92

14.91

0.14

0.00

Euphoria (outlier excluded)

10

0.00 [− 0.10, 0.10]

− 0.04

0.97

8.10

0.52

14.55

Apathy (outlier excluded)

11

− 0.10 [− 0.18, − 0.01]

− 2.25

0.02

5.00

0.89

0.00

  1. Abbreviations: k number of studies, NPS neuropsychiatric symptoms
  2. aHedges’ g = 0 no sex differences; Hedges’ g > 0 female sex associated with NPS; Hedges’ g < 0 male sex associated with NPS