From: Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis
NPS | k | OR [95% CI]a | z statistic | P | Q statistic | P Q statistic | I2 statistic |
---|---|---|---|---|---|---|---|
Any NPS present (outlier excluded) | 4 | 1.35 [0.78, 2.35] | 1.07 | 0.28 | 4.01 | 0.25 | 32.74 |
Psychotic symptoms (outlier excluded) | 4 | 1.62 [1.12, 2.33] | 2.56 | 0.01 | 1.98 | 0.58 | 0.00 |
Depressive symptoms | 20 | 1.60 [1.28, 1.98] | 4.20 | < 0.001 | 51.99 | < 0.001 | 58.19 |
Delusions | 12 | 1.56 [1.28, 1.89] | 4.45 | < 0.001 | 8.51 | 0.67 | 0.00 |
Aberrant motor behavior (outlier excluded) | 6 | 1.47 [1.09, 1.98] | 2.53 | 0.01 | 2.51 | 0.78 | 0.00 |
Anxiety | 8 | 1.42 [0.74, 2.71] | 1.05 | 0.29 | 23.37 | 0.00 | 78.49 |
Eating behavior | 5 | 1.31 [0.97, 1.76] | 1.78 | 0.08 | 5.40 | 0.25 | 22.00 |
Disinhibition | 8 | 1.17 [0.80, 1.70] | 0.81 | 0.42 | 13.54 | 0.06 | 42.07 |
Irritability (outlier excluded) | 5 | 1.14 [0.83, 1.56] | 0.80 | 0.43 | 6.11 | 0.19 | 0.00 |
Hallucinations | 9 | 1.03 [0.79, 1.35] | 0.24 | 0.81 | 9.89 | 0.27 | 14.23 |
Agitation (outlier excluded) | 10 | 1.00 [0.75, 1.35] | 0.01 | 0.99 | 16.63 | 0.06 | 46.06 |
Euphoria | 6 | 0.98 [0.57, 1.68] | − 0.08 | 0.93 | 6.56 | 0.26 | 14.77 |
Apathy | 12 | 0.92 [0.73, 1.17] | − 0.65 | 0.51 | 17.66 | 0.09 | 36.92 |
Sleep disturbances | 8 | 0.86 [0.63, 1.16] | − 0.99 | 0.32 | 14.49 | 0.04 | 62.49 |