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Table 1 Sex differences in the prevalence of neuropsychiatric symptoms in Alzheimer’s disease dementia

From: Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis

NPS

k

OR [95% CI]a

z statistic

P

Q statistic

P Q statistic

I2 statistic

Any NPS present (outlier excluded)

4

1.35 [0.78, 2.35]

1.07

0.28

4.01

0.25

32.74

Psychotic symptoms (outlier excluded)

4

1.62 [1.12, 2.33]

2.56

0.01

1.98

0.58

0.00

Depressive symptoms

20

1.60 [1.28, 1.98]

4.20

< 0.001

51.99

< 0.001

58.19

Delusions

12

1.56 [1.28, 1.89]

4.45

< 0.001

8.51

0.67

0.00

Aberrant motor behavior (outlier excluded)

6

1.47 [1.09, 1.98]

2.53

0.01

2.51

0.78

0.00

Anxiety

8

1.42 [0.74, 2.71]

1.05

0.29

23.37

0.00

78.49

Eating behavior

5

1.31 [0.97, 1.76]

1.78

0.08

5.40

0.25

22.00

Disinhibition

8

1.17 [0.80, 1.70]

0.81

0.42

13.54

0.06

42.07

Irritability (outlier excluded)

5

1.14 [0.83, 1.56]

0.80

0.43

6.11

0.19

0.00

Hallucinations

9

1.03 [0.79, 1.35]

0.24

0.81

9.89

0.27

14.23

Agitation (outlier excluded)

10

1.00 [0.75, 1.35]

0.01

0.99

16.63

0.06

46.06

Euphoria

6

0.98 [0.57, 1.68]

− 0.08

0.93

6.56

0.26

14.77

Apathy

12

0.92 [0.73, 1.17]

− 0.65

0.51

17.66

0.09

36.92

Sleep disturbances

8

0.86 [0.63, 1.16]

− 0.99

0.32

14.49

0.04

62.49

  1. Abbreviations: k number of studies, NPS neuropsychiatric symptoms
  2. aOR odds ratio. OR = 1 no sex differences; OR > 1 female sex associated with NPS; OR < 1 male sex associated with NPS