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Table 3 Derivation of tau PET cut-points, resultant tau positivity rates, and Cohen’s d statistics discriminating tau positivity/negativity for 8 unique thresholding methods

From: What’s the cut-point?: a systematic investigation of tau PET thresholding methods

Method

Cut-point

T+ rate

CSF p-tau Cohen’s d

MMSE Cohen’s d

Logical memory Cohen’s d

Entorhinal/ROC/A− CU

1.97

32.5%

− .80 (95% CI [− 1.15, −.80])

1.14 (95% CI [.87, 1.40])

1.17 (95% CI [.90, 1.44])

Entorhinal/ROC/CU

1.94

37.6%

− 1.00 (95% CI [− 1.35, −.65])

1.12 (95% CI [.85, 1.38])

1.12 (95% CI [.86, 1.38])

Entorhinal/2SD/A− CU

2.39

21.5%

−.96 (95% CI [−.1.39, −.52])

1.65 (95% CI [1.32, .1.97])

1.65 (95% CI [1.33, 1.97])

Entorhinal/2SD/CU

2.45

19.7%

− 1.06 (95% CI [− 1.50, −.61])

1.55 (95% CI [1.22, 1.87])

1.54 (95% CI [1.21, 1.86])

Meta-ROI/ROC/A− CU

1.64

38.7%

− 1.18 (95% CI [− 1.54, −.82])

1.13 (95% CI [.86, 1.39])

.90 (95% CI [.65, 1.16])

Meta-ROI/ROC/CU

1.68

32.8%

− 1.26 (95% CI [− 1.63, −.89])

1.25 (95% CI [.97, 1.52])

.99 (95% CI [.72, 1.25])

Meta-ROI/2SD/A−CU

1.78

22.2%

.1.81 (95% CI [.2.26,.1.35])

1.67 (95% CI [1,34, 1.98])

1.53 (95% CI [1.21, 1.84])

Meta-ROI/2SD/CU

2.08

13.9%

− 1.27 (95% CI [− 1.80, −.74]

1.67 (95% CI [1.30, 2.04])

1.42 (95% CI [1.06, 1.79])

  1. A− amyloid negative, CSF cerebrospinal fluid, CU cognitively unimpaired, MMSE Mini-Mental State Examination, ROC receiver operating characteristics, SD standard deviation, T tau. The largest effect sizes for each outcome variable are presented in bold