Table 2 Diagnostic performance for discriminating mild cognitive impairment (MCI) and Alzheimer’s disease (AD), MCI, and AD from cognitively normal controls
No. | Parameter | Area under the receiver operating characteristic curve (95% confidence interval) | Sensitivity at 80% specificity | p value |
|---|---|---|---|---|
A) MCI and AD vs control | ||||
1 | Measured cpRNFL thickness | 0.69 (0.62–0.75) | 42.7 | Ref |
2 | Retinal vessel density | 0.61 (0.55–0.68) | 35.9 | 0.080 |
3 | Macular layers (mRNFL, mGCL and mIPL) | 0.73 (0.68–0.79) | 51.5 | 0.189 |
4 | Compensated cpRNFL thickness and multiple ocular factors | 0.74 (0.68–0.80) | 56.3 | 0.026 |
5 | Combined (#3 and #4) | 0.80 (0.75–0.86) | 68.0 | < 0.001 |
B) MCI vs control | ||||
1 | Measured cpRNFL thickness | 0.68 (0.61–0.74) | 42.7 | Ref |
2 | Retinal vessel density | 0.60 (0.53–0.67) | 34.0 | 0.092 |
3 | Macular layers (mRNFL, mGCL and mIPL) | 0.71 (0.65–0.78) | 45.6 | 0.393 |
4 | Compensated cpRNFL thickness and multiple ocular factors | 0.74 (0.67–0.80) | 59.2 | 0.020 |
5 | Combined (#3 and #4) | 0.79 (0.73–0.85) | 67.0 | < 0.001 |
C) AD vs control | ||||
1 | Measured cpRNFL thickness | 0.71 (0.63–0.78) | 36.9 | Ref |
2 | Retinal vessel density | 0.64 (0.56–0.72) | 30.1 | 0.225 |
3 | Macular layers (mRNFL, mGCL and mIPL) | 0.76 (0.70–0.83) | 56.3 | 0.086 |
4 | Compensated cpRNFL thickness and multiple ocular factors | 0.79 (0.72–0.85) | 56.3 | 0.025 |
5 | Combined (#3 and #4) | 0.87 (0.82–0.92) | 74.8 | < 0.001 |
D) MCI vs AD | ||||
1 | Measured cpRNFL thickness | 0.58 (0.51–0.66) | 26.9 | Ref |
2 | Retinal vessel density | 0.59 (0.51–0.67) | 36.3 | 0.916 |
3 | Macular layers (mRNFL, mGCL and mIPL) | 0.66 (0.58–0.74) | 37.2 | 0.129 |
4 | Compensated cpRNFL thickness and multiple ocular factors | 0.64 (0.56–0.71) | 35.9 | 0.112 |
5 | Combined (#3 and #4) | 0.72 (0.65–0.79) | 42.1 | 0.003 |