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Table 6 Serum Trx80 associations with CSF Aβ42, p-tau, and t-tau in ApoE4 carriers and non-carriers

From: Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

 

Adjusted for age

Adjusted for diagnosis

ApoE4 non-carriers

ApoE4 carriers

ApoE4 non-carriers

ApoE4 carriers

 

N

β (p)

N

β (p)

N

β (p)

N

β (p)

Aβ42

29

− 0.48 (0.04)

22

0.51 (0.11)

29

 0.36 (0.07)#

22

0.27 (0.25)

t-tau

29

 0.13 (0.60)

22

 0.39 (0.18)

29

 0.38 (0.06)#

22

 0.04 (0.81)

p-tau

29

0.04 (0.87)

22

 0.32 (0.27)

29

 0.19 (0.37)

22

 0.09 (0.62)

p-tau/t-tau

29

0.34 (0.16)

22

0.23 (0.50)

29

0.49 (0.00)

22

0.01 (0.98)

  1. Values are standardized β coefficients (p values) from linear regression models with serum Trx80 levels as a dependent variable in GEDOC cohort. Linear regressions are adjusted for age and disease diagnosis. Corresponding p values are shown from analyses with values adjusted zero-skewness log-transformed as appropriate. p values considered significant (bold) if p < 0.05; #, p < 0.10. N, number of participants with available data for each analysis