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Table 5 Associations between serum Trx80 and neuroimaging and inflammatory markers in the FINGER cohort

From: Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

 

Adjusted for age

β (p)

MRI*

 Total gray matter volume, ml

− 0.07 (0.67)

 Hippocampal volume, ml

− 0.32 (0.01)

 AD signature cortical thickness, mm

− 0.08 (0.61)

 White matter lesions, ml

− 0.11 (0.50)

Inflammatory markers

 IL-1α

0.09 (0.59)

 IL-1β

0.12 (0.47)

 IL-2

0.10 (0.55)

 IL-3

0.19 (0.36)

 IL-4

0.32 (0.07)

 IL-5

0.31 (0.08)

 IL-6

0.30 (0.08)

 IL-7

0.12 (0.49)

 IL-8

0.33 (0.05)

 IL-10

0.16 (0.33)

 IL-12 p40

0.10 (0.56)

 IL-12 p70

0.05 (0.77)

 IL-13

0.33 (0.05)

 IL-15

0.14 (0.41)

 IL-17

0.17 (0.32)

 Interferon-α2

0.29 (0.10)

 Interferon-γ

0.28 (0.10)

 Mip-1a

0.40 (0.03)

 TNF-β

0.30 (0.08)

 Bradykinin

0.32 (0.04)

  1. Values are standardized β coefficients (p values) from linear regression models with serum Trx80 levels as a dependent variable. Linear regressions are adjusted for age. *Brain volumes are shown adjusted to head-size and time between blood sample collection and brain scan; AD signature cortical thickness was calculated as the average of cortical thickness in the entorhinal, inferior temporal, middle temporal, and fusiform regions. p values considered significant (bold) if p < 0.05. MRI magnetic resonance imaging, IL-1 interleukin-1, Mip-1a macrophage inflammatory protein 1a, TNF-α tumor necrosis factor-beta