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Table 2 Demographic, clinical, and biomarker data of the FINGER neuroimaging cohort at baseline

From: Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

 

Number

Mean (±SD)

Demographical data

 Sex, % male/female

26/21

55.32/44.68

 Age, years

47

70.66 (5.06)

Cognitive assessment

 MMSE

47

27.02 (1.78)

ApoE genotype

 ApoE4 carriers, % (yes/no)

14/32

30.43/69.57

 ApoE allele frequencies (%)

  2.3

2

4.35

  2.4

2

4.35

  3.3

30

65.22

  3.4

11

23.91

  4.4

1

2.17

MRI

 *Total gray matter volume, ml

47

575.76 (55.50)

 *Total hippocampal volume, ml

47

7.47 (0.99)

 AD signature cortical thickness, mm

47

2.73 (0.13)

 *White matter lesion volume, ml

46

13.27 (16.18)

 Total intracranial volume, ml

47

1548.82 (252.08)

Serum measurements

 Trx80, ng/ml

47

19.46 (36.37)

Inflammatory markers (pg/ml)

 IL-1α

41

1465.39 (2558.60)

 IL-1β

41

123.47 (379.81)

 IL-2

41

65.23 (159.62)

 IL-3

32

15.93 (9.48)

 IL-4

41

169.00 (239.26)

 IL-5

41

57.16 (78.22)

 IL-6

41

58.17 (57.09)

 IL-7

41

44.73 (22.54)

 IL-8

41

58.17 (57.09)

 IL-10

41

151.23 (165.27)

 IL-12 p40

41

435.83 (639.53)

 IL-12 p70

41

130.07 (149.32)

 IL-13

41

112.00 (157.59)

 IL-15

41

81.81 (85.99)

 IL-17

41

77.17 (104.78)

 Interferon-α2

41

204.32 (149.36)

 Interferon-γ

41

132.48 (178.42)

 Mip-1a

36

43.22 (37.77)

 TNF-β

41

109.24 (146.66)

 Bradykinin

47

6610000 (3870000)

  1. Values are means ± standard deviation (SD) unless otherwise specified. Cognitive scores are mean values of cognitive tests, where higher scores indicate better performance. *Brain volumes are shown unadjusted; AD signature cortical thickness was calculated as the average of cortical thickness in the entorhinal, inferior temporal, middle temporal, and fusiform regions. N, number of participants with available data for each analysis. MRI magnetic resonance imaging; IL-1 interleukin-1, Mip-1a macrophage inflammatory protein 1a, TNF-b tumor necrosis factor-beta