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Table 1 Demographic, clinical, and biomarker data of GEDOC memory clinic cohort

From: Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

 

N

SCI, mean (SD)

N

MCI, mean (SD)

N

AD, mean (SD)

p

Demographic data

 Sex, % men/women

8/17

32.00/68.00

10/14

41.67/58.33

8/17

32.00/68.00

0.72

 Age, years

25

59.00 (7.85)

24

69.21 (6.69)

25

73.40 (10.48)

0.0001

 Years of education

25

14.28 (2.79)

24

11.75 (3.65)

25

10.32 (3.08)

0.001

Cognition

 MMSE test score

25

29.24 (1.16)

23

27.30 (1.84)

25

24.52 (3.63)

0.0001

ApoE genotype

 ApoE4 carrier, % yes/no

6/9

40.00/60.00

10/12

45.45/54.55

6/8

42.86/57.14

0.95

 ApoE allele frequencies, %

  e2/e2

1

2.70

0

0.00

0

0.00

 

  e2/e3

2

5.41

2

6.45

2

6.45

 

  e2/e4

1

2.70

2

6.45

0

0.00

 

  e3/e3

6

16.22

10

32.26

6

19.35

 

  e3/e4

4

10.81

6

19.35

5

16.13

 

  e4/e4

1

2.70

2

6.45

1

3.23

 

  Unknown

22

59.46

9

29.03

17

54.84

 

CSF measurements

 Aβ42, ng/l

37

935.32 (229.86)

31

881.87 (350.37)

31

658.32 (302.59)

0.011

 t-Tau , ng/l

37

224.97 (91.82)

31

325.58 (162.98)

31

499.71 (228.49)

0.001

 p-Tau, ng/l

37

46.46 (15.32)

31

59.13 (25.95)

31

81.03 (28.17)

0.01

Serum measurements

 Trx80, ng/ml

37

3.56 (4.87)

31

28.13 (30.39)

31

25.50 (28.58)

0.0001

  1. Values are means ± SD unless otherwise specified. Between-group differences were analyzed with chi-square and ANOVA as appropriate. Cognitive scores are mean values, where higher scores indicate better performance. ANCOVA tests adjusting for age were used to compare CSF biomarker and Trx80 levels between groups. p value was considered significant (marked in bold) if < 0.05
  2. ApoE4 apolipoprotein E4, SCI subjective cognitive impairment, MCI mild cognitive impairment, AD Alzheimer’s disease, CSF cerebrospinal fluid, Aβ42 amyloid-beta 42 fragment, t-Tau total tau protein, p-Tau phosphorylated tau protein, MMSE mini mental state examination