Table 1 Baseline characteristics of participants at enrollment (n = 97)
Variables | CN | MCIa | AD |
|---|---|---|---|
Number (%) | 55 (56.7) | 26 (26.8) | 16 (16.5) |
Age, years, median (IQR) | 74.0 (70.0–79.0) | 74.0 (68.0–78.5) | 76.5 (74.0–82.0) |
Body mass index, kg/m2, n (%) | |||
<25 (normal) | 35 (63.6) | 18 (69.2) | 12 (75.0) |
≥25 (overweight or obese) | 20 (36.4) | 8 (30.8) | 4 (12.5) |
Sex, female (%) | 28 (50.9) | 13 (50.0) | 7 (43.8) |
Education, years, median (IQR) | 9.0 (6.0–14.0) | 12.0 (6.0–12.25) | 11.0 (8.0–14.8) |
Occupation, n (%) | |||
White collar/professional | 20 (36.4) | 7 (26.9) | 4 (25.0) |
Blue collar | 27 (49.1) | 16 (61.5) | 9 (56.3) |
Household/student/unemployed | 8 (14.5) | 3 (11.5) | 3 (18.8) |
Household income, n (%) | |||
Low (1–29 percentile) | 9 (16.4) | 7 (26.9) | 6 (37.5) |
Middle (30–69 percentile) | 24 (43.6) | 12 (46.2) | 5 (31.3) |
High (70–100 percentile) | 22 (40.0) | 7 (26.9) | 5 (31.3) |
Smoking, n (%) | |||
Never or ex-smoker | 52 (94.5) | 26 (100.0) | 14 (87.5) |
Current smoker | 3 (5.5) | 0 (0.0) | 2 (12.5) |
Charlson comorbidity index, n (%) | |||
0 | 20 (36.4) | 9 (34.6) | 6 (37.5) |
1 | 24 (43.6) | 11 (42.3) | 5 (31.3) |
≥2 | 11 (20.0) | 6 (23.1) | 5 (31.3) |
APOE4 carrier, n (%) | 14 (21.2) | 18 (85.7) | 11 (68.8) |
Mini-Mental State Examination, median (range) | 28.0 (24.0–30.0) | 26.0 (22.0–30.0) | 20.0 (10.0–24.0) |
Cognitive measures (composite z-score), mean (SD) | |||
SNSB attention | −0.07 (0.92) | −0.52 (0.79) | −0.61 (0.94) |
SNSB language and related function | 0.51 (0.65) | 0.02 (1.22) | −2.18 (3.22) |
SNSB visuospatial function | 1.01 (0.68) | 0.17 (1.69) | −2.45 (5.00) |
SNSB memory | 0.73 (1.08) | −0.64 (1.46) | −2.73 (1.30) |
SNSB frontal/executive function | 0.55 (0.80) | −0.47 (1.06) | −2.38 (1.53) |
Amyloid PET (standard uptake value ratio), mean (SD) | 1.13 (0.16) | 1.27 (0.26) | 1.39 (0.20) |
Hippocampal volume, cm3, mean (SD) | 7.68 (0.99) | 7.01 (1.40) | 6.04 (1.27) |