Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Table 5 Association of expression of leading-edge genes from co-expressed gene networks with vascular damage protein levels

Gene	*APOE* genotype	Pathway(s)	I-CAM1		SAA		V-CAM1
Gene	*APOE* genotype	Pathway(s)	β	P-value	β	P-value	β	P-value
C1S	ɛ3/ɛ3	IGR	0.11	0.13	0.24	2.5 × 10⁻³	0.30	2.0 × 10⁻⁴
C2	ɛ3/ɛ3	AR	0.05	0.53	0.17	0.04	0.30	2.2 × 10⁻⁴
CD1D	ɛ3/ɛ3	AR	0.28	3.4 × 10⁻³	0.21	0.05	0.46	1.7 × 10⁻⁵
CD38	ɛ3/ɛ4	IGR	0.09	0.25	0.07	0.41	0.39	6.1 × 10⁻⁶
CFB	ɛ3/ɛ3	IGR	0.16	0.05	0.46	2.2 × 10⁻⁷	0.26	5.4 × 10⁻³
DHX58	ɛ3/ɛ3	IGR	0.11	0.34	0.20	0.13	0.51	7.1 × 10⁻⁵
ELF4	ɛ3/ɛ4	AR	0.32	8.7 × 10⁻⁴	0.46	1.9 × 10⁻⁵	0.26	0.02
FOSL1	ɛ3/ɛ4	TSN	0.20	3.1 × 10⁻⁴	0.18	3.1 × 10⁻³	0.08	0.21
HLA-A	ɛ3/ɛ3	AR; IGR	0.27	0.03	0.38	3.9 × 10⁻³	0.53	7.0 × 10⁻⁵
IDH2	ɛ3/ɛ3	P	0.09	0.43	0.24	0.05	0.61	3.6 × 10⁻⁷
IER3	ɛ3/ɛ4	TSN	0.14	0.06	0.37	3.5 × 10⁻⁶	0.07	0.43
IFITM2	ɛ3/ɛ3	IGR	0.19	0.01	0.48	2.9 × 10⁻⁹	0.18	0.03
IRF7	ɛ3/ɛ4	AR; IGR	0.24	9.5 × 10⁻⁴	0.41	2.8 × 10⁻⁷	0.20	0.02
ISG20	ɛ3/ɛ4	IGR	0.21	3.6 × 10⁻³	0.34	1.9 × 10⁻⁵	0.29	4.4 × 10⁻⁴
LITAF	ɛ3/ɛ4	TSN	0.27	4.1 × 10⁻³	0.39	2.1 × 10⁻⁴	0.43	3.9 × 10⁻⁵
MVP	ɛ3/ɛ3	IGR; P	0.21	0.01	0.42	7.0 × 10⁻⁶	0.45	2.4 × 10⁻⁶
PFKFB3	ɛ3/ɛ4	TSN	0.30	5.6 × 10⁻⁴	0.30	2.6 × 10⁻³	0.35	4.0 × 10⁻⁴
PML	ɛ3/ɛ4	IGR	0.28	0.02	0.47	3.8 × 10⁻	0.50	2.0 × 10⁻⁴
SERPING1	ɛ3/ɛ3	IGR	0.17	0.13	0.35	4.4 × 10⁻³	0.50	4.7 × 10⁻⁵
TNIP2	ɛ3/ɛ4	TSN	0.36	1.9 × 10⁻³	0.59	4.7 × 10⁻⁶	0.19	0.15
TRIP10	ɛ3/ɛ4	TSN	0.32	2.1 × 10⁻⁴	0.35	3.4 × 10⁻⁴	0.06	0.58

I-CAM intercellular adhesion molecule 1, SAA serum amyloid A, V-CAM1 vascular cell adhesion molecule 1, AR allograft rejection, IGR interferon gamma response, P peroxisome, TSN Tnfa signaling via nfkb
Results in bold surpass the multiple testing threshold (P < 4.67 × 10⁻⁴)

ISSN: 1758-9193