Table 4 Significant co-expressed gene pathways in the combined blood and brain datasets

Allograft rejection

ɛ3/ɛ3

−1.89

0.02

C2, HLA-DQA1, FAS, HLA-A, UBE2N, HLA-DOB, LTB, F2R, HLA-DRA, TAP2, B2M, CD1D, CD74, MAP3K7

ɛ3/ɛ4

2.16

7.4 × 10⁻³

IRF4, CCL22, IRF7, CD74, HLA-DRA, ELF4, IL16, IFNGR2, IL27RA, IL1B

Interferon gamma response

ɛ3/ɛ3

−2.56

1.3 × 10⁻⁵

HLA-DQA1, FAS, CFB, BPGM, C1S, HLA-A, LAP3, MVP, PSME2, PSMA2, UBE2L6, SERPING1, DHX58, IFITM2, CD38, B2M, CD74

ɛ3/ɛ4

1.80

0.04

CD274, CD69, BTG1, ISG20, PML, IRF4, NFKBIA, IRF7, CD74, IL10RA, IRF9

Peroxisome

ɛ3/ɛ3

−1.81

0.03

IDH2, EHHADH, MVP, ALDH1A1, SCP2, SOD1, ABCD2, MSH2

ɛ3/ɛ4

1.90

0.03

RDH11, ELOVL5, SLC25A19, CTPS1, SLC23A2, SEMA3C

Tnfa signaling via nfkb

ɛ2/ɛ3

−2.03

0.01

DUSP4, NR4A1, NR4A3, MARCKS, NFAT5, PHLDA1, DUSP2, KYNU, G0S2, ETS2, PTGS2, GCH1, MSC, SOD2, EGR2

ɛ3/ɛ4

2.27

2.5 × 10⁻³

TRIP10, CD69, BTG1, DENND5A, PFKFB3, FOS, NFKBIA, LDLR, IER2, JUN, IL1A, PANX1, PNRC1, DUSP1, IFNGR2, OLR1, MAFF, IL1B, TNIP2, CCL20, BIRC2, IER3, GADD45B, KYNU, LITAF, CCRL2, SPHK1, FOSL1