Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Table 3 Novel differentially expressed genes in the blood or brain within APOE genotype groups

Gene	Dataset	*APOE* ɛ2/ɛ3			*APOE* ɛ3/ɛ3			*APOE* ɛ3/ɛ4			Total
Gene	Dataset	N	Z-score	P-value	N	Z-score	P-value	N	Z-score	P-value	N	Z-score	P-value
FRAS1	Blood	NA	NA	NA	75	−0.24	0.81	31	−4.66	3.2 × 10⁻⁶	132	−2.26	0.02
	Brain	NA	NA	NA	355	−0.97	0.33	126	0.28	0.78	576	−0.49	0.62
	Combined	NA	NA	NA	430	−0.75	0.45	157	−1.23	0.22	708	−1.27	0.20
PIGHP1	Blood	26	1.67	0.09	102	0.43	0.67	31	1.30	0.19	179	1.14	0.25
	Brain	71	4.42	9.8 × 10⁻⁶	355	0.53	0.59	126	0.47	0.64	576	1.98	0.05
	Combined	97	4.67	3.1 × 10⁻⁶	457	0.53	0.59	157	0.87	0.39	755	1.68	0.09

NA not available due to low expression. Bolded P-values pass transcriptome-wide multiple testing threshold (3.3 × 10⁻⁶)

ISSN: 1758-9193